847801-90-5

Upstream product

• 2530-26-9 3-nitropyridine 
• 140-18-1 Benzyl chloroacetate 
• 80352-65-4 2-(3-nitropyridin-4-yl)malonic acid dibenzyl ester 

Downstream Products

• 878483-87-5 3-amino-4-(carboxymethyl)pyridine 
• 847801-91-6 (3-aminopyridin-4-yl)acetic acid benzyl ester 

Relevant academic research and scientific papers

Preparation of 6-azaoxindole (6-azaindol-2(3H)-one) and substituted derivatives

A general synthesis of 6-azaoxindoles, substituted in the 3- and 5-position, has been developed starting from 4-methoxyearbomethyl-3- nitropyridine, via hydrogenation of the nitro group and cyclisation of the resulting 3-amino-4-methoxyearbomethyl-pyridin

Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP)

The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.