848-52-2Relevant academic research and scientific papers
Transition-Metal-Free Arylation and Alkylation of Diarylmethyl p-Tolyl Sulfones with Zinc Reagents
Miao, Maozhong,Yin, Wenguang,Wang, Lei,Chen, Zhengkai,Xu, Jianfeng,Ren, Hongjun
, p. 10602 - 10612 (2018/09/06)
The transition-metal-free synthesis of unsymmetrical and highly functionalized triarylmethanes through arylation of the situ generated o-QMs from diarylmethyl p-tolyl sulfones with aryl zinc reagents is described. Alkyl zinc reagents are also well tolerated in this reaction. Additionally, the straightforward synthesis of the analogue of the antituberculosis agent A and the key precursor of the anti-breast-cancer agent B are achieved by this strategy.
