848143-95-3Relevant academic research and scientific papers
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Futatsugi, Kentaro,Smith, Aaron C.,Tu, Meihua,Raymer, Brian,Ahn, Kay,Coffey, Steven B.,Dowling, Matthew S.,Fernando, Dilinie P.,Gutierrez, Jemy A.,Huard, Kim,Jasti, Jayasankar,Kalgutkar, Amit S.,Knafels, John D.,Pandit, Jayvardhan,Parris, Kevin D.,Perez, Sylvie,Pfefferkorn, Jeffrey A.,Price, David A.,Ryder, Tim,Shavnya, Andre,Stock, Ingrid A.,Tsai, Andy S.,Tesz, Gregory J.,Thuma, Benjamin A.,Weng, Yan,Wisniewska, Hanna M.,Xing, Gang,Zhou, Jun,Magee, Thomas V.
, p. 13546 - 13560 (2020)
Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resistance. Ketohexokinase (KHK) converts fructose to fructose-1
Xanthine Derivatives a Useful as Muscarinic Receptor Antagonists
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Page/Page column 6, (2009/01/24)
This present invention generally relates to xanthine derivatives as muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscari
XANTHINE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS
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Page/Page column 11, (2008/06/13)
This present invention generally relates to xanthine derivatives as muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscari
