848362-79-8

Basic information

• Product Name: 1,4-Benzenediol, 2,3,5-trimethyl-6-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]-, diacetate
• CAS NO: 848362-79-8
• Molecular Formula: C33H54O4
• Molecular Weight: 514.789
• Mol File: 848362-79-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,4-Benzenediol, 2,3,5-trimethyl-6-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]-, diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Benzenediol, 2,3,5-trimethyl-6-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]-, diacetate(848362-79-8)
• EPA Substance Registry System: 1,4-Benzenediol, 2,3,5-trimethyl-6-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]-, diacetate(848362-79-8)

Safety Data

• Hazardous Substances Data: 848362-79-8(Hazardous Substances Data)

Upstream product

• 848362-77-6 2,3,5-trimethyl-6-(3-methylbut-2-en-1-yl)benzene-1,4-diyl diacetate 
• 2140-82-1 2,6,10,14-tetramethyl-1-pentadecene 
• 7541-49-3 3,7,11,15-tetramethyl-2-hexadecen-1-ol 
• 93-97-0 benzoic acid anhydride 
• 36592-62-8 4-acetoxy-2,3,5-trimethylphenol 
• 502-69-2 6,10,14-Trimethyl-2-pentadecanon 
• 700-13-0 Trimethylhydroquinone 
• 505-32-8 isophytol 
• 870-63-3 prenyl bromide 
• 556-82-1 3-methyl-2-buten-1-ol 
• 848362-63-0 4-hydroxy-2,3,6-trimethyl-5-(3-methylbut-2-en-1-yl)phenyl acetate 
• 108-24-7 acetic anhydride 
• 64-18-6 formic acid 
• 74515-24-5 3,5,6-trimethyl-2-phytylhydroquinone 

Relevant articles and documents

A new route to vitamin E Key-intermediates by olefin cross-metathesis

Ru-Catalyzed olefin cross-metathesis (CM) has been successfully applied to the synthesis of several phytyl derivatives (2b, 2d-f, 3b) with a trisubstituted C=C bond, as useful intermediates for an alternative route to α-tocopheryl acetate (vitamin E acetate; 1b) (Scheme 1). Using the second-generation Grubbs catalyst RuCl2(C21H 26N2)(CHPh)PCy3, (Cy = cyclohexyl; 4a) and Hoveyda-Grubbs catalyst RuCl2(C21H26N 2){CH-C6H4(O-iPr)-2} (4b), the reactions were performed with various C-allyl (5a-f, 7a,b) and O-allyl (8a-d) derivatives of trimethylhydroquinone-1-acetate as substrates. 2,6,10,14-Tetramethylpentadec-1-ene (6a) and derivatives 6c-e of phytol (6b) as well as phytal (6f) were employed as olefin partners for the CM reactions (Schemes 2 and 5). The vitamin E precursors could be prepared in up to 83% isolated yield as (E/Z)-mixtures.

ISOLATION AND IDENTIFICATION OF INTERMEDIATE COMPOUNDS IN THE SYNTHESIS OF DL-α-TOCOPHEROL

-