84850-31-7Relevant academic research and scientific papers
Combination of enantioselective metal catalysis and organocatalysis: Enantioselective sequential hydroformylation/ aldol reactions
Chercheja, Serghei,Nadakudity, Sailendra K.,Eilbracht, Peter
experimental part, p. 637 - 643 (2010/06/19)
This work reports the possibility of con-trolling the sense of enantio- and diastereoinduc-tions in the sequential hydroformylation and aldol reactions via the judicious combination of a chiral metal catalyst with a chiral organocatalyst. The dia-stereoselectivity of the reaction between styrene, syngas and acetone can be increased by using a matched pair of catalysts, [rhodium/(25, 4S)-Chira-phite]/(S)-organocatalyst and decreased, but not in-verted, by using a mismatched pair of catalysts, [rhodium/(2/R, 4/R)-Chiraphite]/(S)-organocatalyst.
