848675-00-3Relevant academic research and scientific papers
Diverging DOS strategy using an allene-containing tryptophan scaffold and a library design that maximizes biologically relevant chemical space while minimizing the number of compounds
Painter, Thomas O.,Wang, Lirong,Majumder, Supriyo,Xie, Xiang-Qun,Brummond, Kay M.
, p. 166 - 174 (2011/06/18)
A diverging diversity-oriented synthesis (DOS) strategy using an allene-containing tryptophan as a key starting material was investigated. An allene-yne substituted derivative of tryptophan 12 gave indolylmethylazabicyclooctadiene 17 when subjected to a m
Heterocyclic α-alkylidene cyclopentenones obtained via a Pauson-Khand reaction of amino acid derived allenynes. A scope and limitation study directed toward the preparation of a tricyclic pyrrole library
Brummond, Kay M.,Curran, Dennis P.,Mitasev, Branko,Fischer, Stefan
, p. 1745 - 1753 (2007/10/03)
(Chemical Equation Presented) The synthesis of a novel class of tricyclic pyrroles has been accomplished by using a Pauson-Khand/Stetter/Paal-Knorr reaction sequence. Full details of the Pauson-Khand reaction of amino acid tethered allenynes 4a-e and 9a-d
