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84873-15-4

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84873-15-4 Usage

General Description

p-Hydroxyphenethyl trans-ferulate is a chemical compound that belongs to the class of hydroxycinnamic acids. It is a natural plant compound found in various plant species, including rice bran and oats. p-Hydroxyphenethyl trans-ferulate has been found to have antioxidant and anti-inflammatory properties, making it potentially beneficial for human health. Studies have shown that p-Hydroxyphenethyl trans-ferulate may be effective in protecting cells from oxidative damage and reducing inflammation in the body. Additionally, it has been investigated for its potential role in preventing chronic diseases such as cancer and cardiovascular disease. This chemical compound has shown promise in various research studies, although more research is needed to fully understand its potential benefits and mechanisms of action.

Check Digit Verification of cas no

The CAS Registry Mumber 84873-15-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,8,7 and 3 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 84873-15:
(7*8)+(6*4)+(5*8)+(4*7)+(3*3)+(2*1)+(1*5)=164
164 % 10 = 4
So 84873-15-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H18O5/c1-22-17-12-14(4-8-16(17)20)5-9-18(21)23-11-10-13-2-6-15(19)7-3-13/h2-9,12,19-20H,10-11H2,1H3/b9-5+

84873-15-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name p-Hydroxyphenethyl trans-ferulate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:84873-15-4 SDS

84873-15-4Relevant articles and documents

Synthesis of amide and ester derivatives of cinnamic acid and its analogs: Evaluation of their free radical scavenging and monoamine oxidase and cholinesterase inhibitory activities

Takao, Koichi,Toda, Kazuhiro,Saito, Takayuki,Sugita, Yoshiaki

, p. 1020 - 1027 (2017/11/17)

A series of cinnamic acid derivatives, amides (1–12) and esters (13–22), were synthesized, and structure–activity relationships for antioxidant activity, and monoamine oxidases (MAO) A and B, acetylcholinesterase, and butyrylcholinesterase (BChE) inhibitory activities were analyzed. Among the synthesized compounds, compounds 1–10, 12–18, and rosmarinic acid (23), which contained catechol, o-methoxyphenol or 5-hydroxy-indole moieties, showed potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity. Compounds 9–11, 15, 17–22 showed potent and selective MAO-B inhibitory activity. Compound 20 was the most potent inhibitor of MAO-B. Compounds 18 and 21 showed moderate BChE inhibitory activity. In addition, compound 18 showed potent antioxidant activity and MAO-B inhibitory activity. In a comparison of the cinnamic acid amides and esters, the amides exhibited more potent DPPH free radical scavenging activity, while the esters showed stronger inhibitory activities against MAO-B and BChE. These results suggested that cinnamic acid derivatives such as compound 18, p-coumaric acid 3,4-dihydroxyphenethyl ester, and compound 20, p-coumaric acid phenethyl ester, may serve as lead compounds for the development of novel MAO-B inhibitors and candidate lead compounds for the prevention or treatment of Alzheimer’s disease.

Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters

Maresca, Alfonso,Akyuz, Gulay,Osman, Sameh M.,Alothman, Zeid,Supuran, Claudiu T.

, p. 7181 - 7188 (2015/11/16)

A series of phenolic acid esters incorporating caffeic, ferulic, and p-coumaric acid, and benzyl, m/p-hydroxyphenethyl- as well as p-hydroxy-phenethoxy-phenethyl moieties were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). Many of the mammalian isozymes of human (h) or murine (m) origin, hCA I-hCA XII, mCA XIII and hCA XIV, were inhibited in the submicromolar range by these derivatives (with KIs of 0.31-1.03 μM against hCA VA, VB, VI, VII, IX and XIV). The off-target, highly abundant isoforms hCA I and II, as well as hCA III, IV and XII were poorly inhibited by many of these esters, although the original phenolic acids were micromolar inhibitors. These phenols, like others investigated earlier, possess a CA inhibition mechanism distinct of the sulfonamides/sulfamates, clinically used drugs for the treatment of a multitude of pathologies, but with severe side effects due to hCA I/II inhibition. Unlike the sulfonamides, which bind to the catalytic zinc ion, phenols are anchored at the Zn(II)-coordinated water molecule, binding more externally within the active site cavity, and making contacts with amino acid residues at the entrance of the active site. As this is the region with the highest variability between the many CA isozymes found in mammals, this class of compounds shows isoform-selective inhibitory profiles, which may be exploited for obtaining pharmacological agents with less side effects compared to other classes of inhibitors.

A new phenolic compound from Heracleum lanatum Michx. var. nippinicum Hara. II

Nakata,Sashida,Shimomura

, p. 4554 - 4556 (2007/10/02)

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