848738-27-2

Basic information

• Product Name: Benzoic acid, 4-[(3-phenyl-2-propynyl)amino]-, ethyl ester
• CAS NO: 848738-27-2
• Molecular Formula: C18H17NO2
• Molecular Weight: 279.338
• Mol File: 848738-27-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(3-phenyl-2-propynyl)amino]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(3-phenyl-2-propynyl)amino]-, ethyl ester(848738-27-2)
• EPA Substance Registry System: Benzoic acid, 4-[(3-phenyl-2-propynyl)amino]-, ethyl ester(848738-27-2)

Safety Data

• Hazardous Substances Data: 848738-27-2(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 101248-36-6 ethyl 4-(prop-2-ynylamino)benzoate 
• 94-09-7 p-aminoethylbenzoate 
• 1794-48-5 1-bromo-3-phenylprop-2-yne 

Downstream Products

• 1217436-70-8 ethyl 4-phenylquinoline-6-carboxylate 

Relevant articles and documents

Ag-Catalyzed or Ag/PPh3-Catalyzed Chemoselective Switchable Cascade Reactions of N-Propargyl Thiocarbamoyl Fluorides and Malonate Esters

The divergent chemoselective synthesis of 2-methylene-2,3-dihydrothiazoles and 4-benzylidene pyrrolidine-2-thiones (most with E stereoselectivity) from N-propargyl thiocarbamoyl fluorides and malonate esters in moderate to excellent yields with a broad substrate scope and functional group tolerance has been accomplished. AgNTf2 catalyst at 60 °C in dichloroethane provided 4-benzylidene pyrrolidine-2-thiones. AgOTf catalyst and PPh3 ligand in refluxing acetonitrile resulted in a complete switch in the reactivity of formed α,α-diester thioamide intermediates followed by isomerization to access 2-methylene-2,3-dihydrothiazoles.

Synthesis of substituted quinolines by electrophilic cyclization of N-(2-alkynyl)anilines

(Chemical Equation Presented) Quinolines substituted in the 3-position by an iodo or phenylseleno group are readily prepared in good to excellent yields by the reaction of propargylic anilines with appropriate electrophiles under mild reaction conditions.