848900-50-5Relevant academic research and scientific papers
A convenient stereoselective synthesis of 5-hydroxy-3-oxoesters and 3-hydroxy-5-oxoesters
??d?o-Dobrowolska, Anna,Schrittwieser, Joerg H.,Grischek, Barbara,Koszelewski, Dominik,Kroutil, Wolfgang,Ostaszewski, Ryszard
, p. 797 - 802 (2017)
A biocatalytic approach was employed for the asymmetric reduction of sterically demanding ketones to prepare 3-hydroxy-5-oxo-5-phenylpentanoates and 5-hydroxy-3-oxo-5-phenylpentanoates. Screening a collection of microorganisms led to the identification of
Candida Rugosa lipase-catalyzed kinetic resolution of β-hydroxy- β-arylpropionates and δ-hydroxy-δ-aryl-β-oxo-pentanoates
Xu, Chengfu,Yuan, Chengye
, p. 2169 - 2186 (2007/10/03)
A simple and convenient method was reported for the preparation of optically active β-hydroxy-β-arylpropionates, δ-hydroxy-δ- aryl-β-oxo-pentanoates and their butyryl derivatives via CRL-catalyzed hydrolysis. The optically active products are potential precursors of some chiral pharmaceuticals and natural products.
A Chemoenzymatic Approach to Optically Active 5-Hydroxy-3-oxocarboxylates
Xu, Chengfu,Zhang, Yonghui,Yuan, Chengye
, p. 485 - 488 (2007/10/03)
Enzymatic hydrolysis was applied to the preparation of certain chiral 5-hydroxy-3-oxo-carboxylates that are potential precursors for natural product synthesis via the formation of lactone derivatives and tetrahydropyran rings.
