871505-88-3Relevant academic research and scientific papers
A convenient stereoselective synthesis of 5-hydroxy-3-oxoesters and 3-hydroxy-5-oxoesters
??d?o-Dobrowolska, Anna,Schrittwieser, Joerg H.,Grischek, Barbara,Koszelewski, Dominik,Kroutil, Wolfgang,Ostaszewski, Ryszard
, p. 797 - 802 (2017/06/13)
A biocatalytic approach was employed for the asymmetric reduction of sterically demanding ketones to prepare 3-hydroxy-5-oxo-5-phenylpentanoates and 5-hydroxy-3-oxo-5-phenylpentanoates. Screening a collection of microorganisms led to the identification of
New selective carbonic anhydrase IX inhibitors: Synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides
Rogez-Florent, Tiphaine,Meignan, Samuel,Foulon, Catherine,Six, Perrine,Gros, Abigaelle,Bal-Mahieu, Christine,Supuran, Claudiu T.,Scozzafava, Andrea,Frederick, Raphael,Masereel, Bernard,Depreux, Patrick,Lansiaux, Amelie,Goossens, Jean-Francois,Gluszok, Sebastien,Goossens, Laurence
, p. 1451 - 1464 (2013/04/10)
Carbonic anhydrase (CA) IX expression is increased upon hypoxia and has been proposed as a therapeutic target since it has been associated with poor prognosis, tumor progression and pH regulation. We report the synthesis and the pharmacological evaluation
