848902-19-2Relevant articles and documents
Indole-linked 1,2,3-triazole derivatives efficiently modulate COX-2 protein and PGE2 levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kβ nexus
Aslam, Tooba,Basha, Fatima Z.,Choudhary, M. Iqbal,Iqbal, Shazia,Jahan, Humera,Khan, Maria Aqeel,Siddiqui, Nimra Naz
, (2022/01/19)
Aims: AGEs augment inflammatory responses by activating inflammatory cascade in monocytes, and hence lead to vascular dysfunction. The current study aims to study a plausible role and mechanism of a new library of indole-tethered 1,2,3-triazoles 2-13 in A
Electrochemical Difunctionalization of Styrenes via Chemoselective Oxo-Azidation or Oxo-Hydroxyphthalimidation
Jiang, Haobin,Wang, Feng,Ye, Zenghui,Zhang, Fengzhi,Zhu, Rongjin
supporting information, p. 8240 - 8245 (2021/11/17)
Atom- and step-economic oxo-azidation and oxo-hydroxyphthalimidation of styrenes have been developed under mild electrolytic conditions, respectively. Various valuable alpha-azido or hydroxyphthalimide aromatic ketones were synthesized efficiently from readily available styrenes, azides, and N-hydroxyphthalimides. Mechanism studies show that two different pathways involved in these two transformations.
Visible-light-enabled oxyazidation of alkenes leading to α-azidoketones in air
Wei, Wei,Cui, Huanhuan,Yue, Huilan,Yang, Daoshan
supporting information, p. 3197 - 3202 (2018/07/29)
A new and facile visible-light-enabled method for the synthesis of α-azidoketones has been developed via oxyazidation of alkenes with TMSN3 in air at room temperature. A series of α-azidoketones could be easily and efficiently obtained in moder
Method for preparing alpha-azidoketone compounds based on photocatalysis
-
Paragraph 0142; 0143; 0144, (2018/10/11)
The invention discloses a method for preparing alpha-azidoketone compounds based on photocatalysis. The method is based on a reaction formula shown in the description, wherein R is optionally-substituted aryl, heteroaryl or 1-12 carbon alkyl; R is o
In vitro α-glucosidase inhibition by non-sugar based triazoles of dibenzoazepine, their structure-Activity relationship, and molecular docking
Khan, Maria A.,Javaid, Kulsoom,Batool, Farhana,Basha, Fatima Z.,Choudhary, Muhammad I.,Wadood, Abdul,Jamal, Alam,Fazal-Ur-Rehman, Saba
, p. 698 - 704 (2018/02/02)
Background: α-Glucosidase inhibitors (AGIs) have been reported for their clinical potential against postprandial hyperglycemia, which is responsible for the risks associated with diabetes mellitus 2 and cardiovascular diseases (CVDs). Besides, a number of
Synthesis and in vitro evaluation of dibenzoazepine triazole derivatives: A novel class of antileishmanial agents
Khan, Maria Aqeel,Saleem, Aliyan,Ghouri, Nida,Hameed, Abdul,Iqbal Choudhary,Basha, Fatima Z.
, p. 597 - 606 (2016/03/22)
In the present study, a series of dibenzoazepine triazole derivatives (24-39) were synthesized and evaluated for their in vitro bioactivities including antiglycation, antibacterial, DPPH radical scavenging, urease inhibition, antileishmanial and immunomod
New 1,3-oxazolo[4,5-c]quinoline derivatives: Synthesis and evaluation of antibacterial and antituberculosis properties
Eswaran, Sumesh,Adhikari, Airody Vasudeva,Ajay Kumar
experimental part, p. 957 - 966 (2010/04/26)
A new class of fused oxazoloquinoline derivatives was synthesized starting from 2-bromo-1-phenylethanones 1a-b through multi-step reactions. The newly synthesized compounds were evaluated for their in vitro antibacterial against Escherichia coli (ATTC-259
Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors
Harris, Philip A.,Cheung, Mui,Hunter III, Robert N.,Brown, Matthew L.,Veal, James M.,Nolte, Robert T.,Wang, Liping,Liu, Wendy,Crosby, Renae M.,Johnson, Jennifer H.,Epperly, Andrea H.,Kumar, Rakesh,Luttrell, Deirdre K.,Stafford, Jeffrey A.
, p. 1610 - 1619 (2007/10/03)
A series of derivatives of 2-anilino-5-phenyloxazole (5) has been identified as inhibitors of VEGFR2 kinase. Herein we describe the structure-activity relationship (SAR) of this novel template. Optimization of both aryl rings led to very potent inhibitors at both the enzymatic and cellular levels. Oxazole 39 had excellent solubility and good oral PK when dosed as the bis-mesylate salt and demonstrated moderate in vivo efficacy against HT29 human colon tumor xenografts. X-ray crystallography confirmed the proposed binding mode, and comparison of oxazoles 39 and 46 revealed interesting differences in orientation of 2-pyridyl and 3-pyridyl rings, respectively, attached at the meta position of the 5-phenyl ring.
