849024-41-5

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 849024-40-4 3-(4-methoxybenzoyl)-4-(4-methoxyphenyl)furan-2(5H)-one 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 
• 4136-21-4 p-methoxybenzoylmethanol 
• 87769-44-6 6-(4-methoxyphenyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 54441-74-6 tert-butyl 3-(4-methoxyphenyl)-3-oxopropanoate 
• 849024-39-1 3-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-5H-furan-2-one 
• 849024-38-0 4-bromo-3-[hydroxy-(4-methoxy-phenyl)-methyl]-5H-furan-2-one 

Downstream Products

• 849024-42-6 (Z)-3-(4-hydroxybenzoyl)-5-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one 

Relevant academic research and scientific papers

Versatile synthesis of acylfuranones by reaction of acylketenes with α-hydroxy ketones: Application to the one-step multicomponent synthesis of cadiolide B and its analogues

Functionalized acylfuranones have been prepared in a one-step procedure by thermal fragmentation of the corresponding dioxinones in the presence of hydroxy ketones in basic conditions. Multicomponent reactions also occur on addition of an aldehyde as a third reaction partner resulting in an expeditious access to cadiolide B and its analogues. A new method for the synthesis of acylfuranones is described based on the fragmentation of dioxinones to acylketenes followed by trapping with hydroxy ketones. Addition of an aldehyde as a third reaction partner leads to a supplementary aldolization/crotonization sequence resulting in an expeditious synthesis of cadiolide B and its analogues. Copyright

Short and efficient synthesis of cadiolide B

The first synthesis of cadiolide B has been achieved in 6 steps and 42% overall yield from 4-bromo-2(5H)-furanone. The pathway involves sequential, regiocontrolled introduction of the three furanone substituents by means of aldol reactions and Suzuki cros