849060-28-2Relevant academic research and scientific papers
Mononuclear Salen-Sodium Ion Pairs as Catalysts for Isoselective Polymerization of rac-Lactide
Cui, Yaqin,Jiang, Jinxing,Mao, Xiaoyang,Wu, Jincai
supporting information, p. 218 - 227 (2019/01/04)
A series of mononuclear salen-sodium anions, as the first examples, were synthesized with tetra-alkyl ammonium as a counterpart cation. These complexes are efficient catalysts for the isoselective ring-opening polymerization of rac-lactide; the molecular weights of polymers are under control and molecular weight distributions are narrow when five equivalents of BnOH is used as an initiator. The best isoselectivity value of Pm = 0.82 was achieved at -70 °C. The experimental results together with a density functional theory calculation show that a ligand-assisted activated monomer mechanism is more reasonable than an activated monomer mechanism for this system.
Zn-mediated synthesis of 3-substituted indoles using a three-component reaction approach
Anselmo, Daniele,Escudero-Adan, Eduardo C.,Martinez Belmonte, Marta,Kleij, Arjan W.
, p. 4694 - 4700 (2013/01/15)
The synthesis of 3-substituted indoles was investigated through a multicomponent reaction (MCR) approach by using aldehydes, indole and malononitrile as the reagents. The reaction was catalyzed by Lewis acidic Zn(salphen) complexes and their performance was compared with a number of other ZnII structures and M(salphen)s, which showed the Zn(salphen)s to be superior. However, the complex nature of this three-component reaction (3-CR) results in substantial byproduct formation that arises from the intermediate benzylidene malononitrile species. The 3-CR was studied in detail that covered the influence of the base, solvent, reagent stoichiometry and also involved stability studies. The results led to a mechanistic proposal in which the benzylidene malononitrile intermediate plays a central role; it is one of the major species that is formed in most of the catalytic reactions studied. Furthermore, it provided a prelude for the in situ reaction with the malononitrile reagent, which most probably affords a complex mixture of N-containing heterocycles. Copyright
