849112-77-2Relevant academic research and scientific papers
Stereoselective synthesis of conformationally constrained 2′-deoxy-4′-thia β-anomeric spirocyclic nucleosides featuring either hydroxyl configuration at C5′
Dong, Shuzhi,Paquette, Leo A.
, p. 1580 - 1596 (2005)
(Chemical Equation Presented) An enantioselective approach to 2′-deoxy-4′-thia spirocyclic nucleosides featuring an α- or β-hydroxyl substituent at C-5′ of the carbocyclic ring is detailed. The starting point is the mandelate acetal 8. The overall strateg
Spirocyclic restriction of nucleosides
Paquette, Leo A.
, p. 7 - 17 (2004)
The concept of spirocyclic restriction as applied broadly to the field of nucleoside mimics makes possible the generation of diastereomeric pairs configured with a syn- or anti-oriented hydroxyl substituent at C5′. The development of concise synthetic rou
