849235-59-2Relevant academic research and scientific papers
Optimization of potent and selective quinazolinediones: Inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity
Matharu, Daljit S.,Flaherty, Daniel P.,Simpson, Denise S.,Schroeder, Chad E.,Chung, Donghoon,Yan, Dan,Noah, James W.,Jonsson, Colleen B.,White, E. Lucile,Aubé, Jeffrey,Plemper, Richard K.,Severson, William E.,Golden, Jennifer E.
, p. 10314 - 10328 (2015/02/19)
A quinazolinedione-derived screening hit 2 was discovered with cellular antiviral activity against respiratory syncytial virus (CPE EC50 = 2.1 μM), moderate efficacy in reducing viral progeny (4.2 log at 10 μM), and marginal cytotoxic liability
INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS
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, (2014/01/08)
Described herein are compounds, pharmaceutical compositions and methods for treating a respiratory syncytial virus infection in a subject, or for inhibiting replication of respiratory syncytial virus.
N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors
Vaisburg, Arkadii,Paquin, Isabelle,Bernstein, Naomy,Frechette, Sylvie,Gaudette, Frederic,Leit, Silvana,Moradei, Oscar,Raeppel, Stephane,Zhou, Nancy,Bouchain, Giliane,Woo, Soon Hyung,Jin, Zhiyun,Gillespie, Jeff,Wang, James,Fournel, Marielle,Yan, Pu Theresa,Trachy-Bourget, Marie-Claude,Robert, Marie-France,Lu, Aihua,Yuk, Jimmy,Rahil, Jubrail,MacLeod, A. Robert,Besterman, Jeffrey M.,Li, Zuomei,Delorme, Daniel
, p. 6729 - 6733 (2008/03/18)
A variety of N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides were designed and synthesized. These compounds were shown to inhibit recombinant human HDAC1 with IC50 values in the sub-micromolar range. In human cancer cells growing in culture these compounds induced hyperacetylation of histones, induced the expression of the tumor suppressor protein p21WAF1/Cip1, and inhibited cellular proliferation. Certain compounds of this class also showed in vivo activity in various human tumor xenograft models in mice.
