849343-53-9Relevant academic research and scientific papers
Efficient chemoenzymatic synthesis of phenylacetylrinvanil: An ultrapotent capsaicinoid
Castillo, Edmundo,Regla, Ignacio,Demare, Patricia,Luviano-Jardón, Axel,López-Munguía, Agustín
experimental part, p. 2869 - 2873 (2009/05/07)
The straightforward synthesis of phenylacetylrinvanyl (PhAR), an ultrapotent capsaicinoid is described. The process starts with the quantitative synthesis of methyl ricinoleate (MeRic) by castor oil methanolysis. Afterwards, two alternative routes are pos
TRPV1 AGONISTS, FORMULATIONS CONTAINING THEM AND USES THEREOF
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Page/Page column 9-10, (2010/02/15)
The compounds of the general formula (I) in which X is represents two hydrogen atoms, a π-bond, oxygen or methylene; R2 is a C6-C12 aryl, or arylalkyl residue; R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatme
Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential
Appendino, Giovanni,De Petrocellis, Luciano,Trevisani, Marcello,Minassi, Alberto,Daddario, Nives,Moriello, Aniello Schiano,Gazzieri, David,Ligresti, Alessia,Campi, Barbara,Fontana, Gabriele,Pinna, Christian,Geppetti, Pierangeio,Di Marzo, Vincenzo
, p. 561 - 570 (2007/10/03)
Olvanil (N-9-Z-octadecenoyl-vanillamide) is an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels that lack the pungency of capsaicin and was developed as an oral analgesic. Vanillamides are unmatched in terms of structural simplici
