849364-86-9

Upstream product

• 181705-73-7 (3S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-hexahydro-indolizine-5,8-dione 
• 181961-50-2 (3S,8R,8aR)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-hydroxy-hexahydro-indolizin-5-one 
• 181705-72-6 (3S,8S,9R)-3-(tert-butyldiphenylsilanyloxymethyl)-8-hydroxyhexahydroindolizin-5-one 
• 181705-71-5 (5S,2'S,5'S)-5-[5'-(tert-butyldiphenylsilyloxymethyl)pyrrolidin-2'yl]-tetrahydrofuran-2-one 
• 181705-78-2 (3S,6S,8R,8aR)-6-Azido-8-benzyloxy-5-oxo-octahydro-indolizine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester 
• 100-39-0 benzyl bromide 
• 87-51-4 indole-3-acetic acid 
• 181705-79-3 (3S,6S,8R,8aR)-8-Benzyloxy-6-(2-1H-indol-3-yl-acetylamino)-5-oxo-octahydro-indolizine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester 

Relevant academic research and scientific papers

A versatile synthesis of a β-turn peptidomimetic scaffold: An approach towards a designed model antagonist of the tachykinin NK-2 receptor

A general and stereocontrolled synthesis of an azabicyclo[4.3.0]nonane amino acid template with an appended substitutent at C-5 was developed. The approach allows for stereochemical and functional variations that extend the utility of these rigid amino acid motifs as peptidomimetics. The synthesis of a weakly active but specific NK-2 receptor antagonist is described.