84940-32-9Relevant academic research and scientific papers
Synthesis of Some 2,5-Benzoxazocine and 2,6-Benzoxazonine Derivatives from ω-(Dihydroisoindol-2-yl)alkanol Precursors by Means of Cyanogen Bromide
Bremner, John B.,Thirasasana, Narumol
, p. 2307 - 2314 (2007/10/02)
Reaction of cyanogen bromide with 2-(1-phenyl-2,3-dihydro-1H-isoindol-2-yl)ethanol (5a) gave 1-phenyl 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine-5-carbonitrile (6a) in a low to moderate yield..Similarly, 3-(1-phenyl-2,3-dihydro-1H-isoindol-2-yl)propan-1-ol (5c) gave 1-phenyl-1,3,4,5,6,7-hexahydro-2,6-benzoxazonine-6-carbonitrile (6c).The analogous 1-(4-methoxyphenyl) derivatives of both medium ring systems were also prepared, and some mechanistic aspects of the results are discussed.Conversion of (6a) into the analgesic, Nefopam, is described.
