84940-24-9Relevant academic research and scientific papers
The Reaction of Arylmagnesium Bromides with N-(ω-Bromoalkyl)phthalimides
Braun, Loren L.,Xia, Jing,Cooney, Mark J.,Ahmed, Mohammed K.,Isaacson, Eugene I.
, p. 1441 - 1445 (2007/10/02)
The reaction of the N-(ω-bromoalkyl)phthalimides, 1 and 2, with a series of arylmagnesium bromides in tetrahydrofuran yielded the corresponding oxazoloisoindoles 4a-4h and oxazinoisoindoles 5a-5f.At low temperatures, phenylmagnesium bromide, on treatment
Synthesis of Some 2,5-Benzoxazocine and 2,6-Benzoxazonine Derivatives from ω-(Dihydroisoindol-2-yl)alkanol Precursors by Means of Cyanogen Bromide
Bremner, John B.,Thirasasana, Narumol
, p. 2307 - 2314 (2007/10/02)
Reaction of cyanogen bromide with 2-(1-phenyl-2,3-dihydro-1H-isoindol-2-yl)ethanol (5a) gave 1-phenyl 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine-5-carbonitrile (6a) in a low to moderate yield..Similarly, 3-(1-phenyl-2,3-dihydro-1H-isoindol-2-yl)propan-1-ol (5c) gave 1-phenyl-1,3,4,5,6,7-hexahydro-2,6-benzoxazonine-6-carbonitrile (6c).The analogous 1-(4-methoxyphenyl) derivatives of both medium ring systems were also prepared, and some mechanistic aspects of the results are discussed.Conversion of (6a) into the analgesic, Nefopam, is described.
