849465-31-2Relevant academic research and scientific papers
Modified mannose disaccharides as substrates and inhibitors of a polyprenol monophosphomannose-dependent α-(1→6)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesis
Subramaniam, Vinodhkumar,Gurcha, Sudagar S.,Besra, Gurdyal S.,Lowary, Todd L.
, p. 1083 - 1094 (2005)
A panel of α-(1→6)-linked mannose disaccharides (5-8) in which the 2′-OH group has been replaced, independently, by deoxy, fluoro, amino, and methoxy functionalities has been synthesized. Evaluation of these compounds as potential substrates or inhibitors
Novel synthetic (1 → 6)-α-d-mannodisaccharide substrates support processive mannosylation catalysed by the mycobacterial cell envelope enzyme fraction
Lattova, Erika,Svetlikova, Zuzana,Mikusova, Katarina,Perreault, Helene,Polakova, Monika
, p. 17784 - 17792 (2013/10/01)
Three new (1 → 6)-α-d-mannodisaccharides with cyclohexylalkyl or octylsulfonyl function like aglycone were synthesized and screened in the mycobacterial mannosyltransferase assay. 2-Cyclohexylethyl (1 → 6)-α-d-Man2 acted as the best acceptor substrate, wh
