84955-32-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxy-7H-Pyrrolo[2,3-d]Pyrimidin-2-amine is used as an anticancer agent for its potential to inhibit the proliferation of cancer cells by targeting cyclin-dependent kinases (CDKs). This makes it a promising candidate for the development of novel therapeutics against various types of cancer.
Used in Neurodegenerative Disease Research:
4-Methoxy-7H-Pyrrolo[2,3-d]Pyrimidin-2-amine is also being studied for its potential use in the treatment of neurodegenerative diseases. Its ability to modulate cellular processes involved in these conditions suggests that it may have therapeutic benefits for patients suffering from such disorders.
Used in Inflammatory Disorder Research:
In addition to its potential applications in oncology and neurodegenerative disease research, 4-Methoxy-7H-Pyrrolo[2,3-d]Pyrimidin-2-amine has been investigated for its potential role in the treatment of inflammatory disorders. Its effects on cellular processes related to inflammation indicate that it may offer new avenues for the development of anti-inflammatory therapies.

Upstream product

• 7355-55-7 2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 
• 84981-48-6 2-Amino-4-(2-hydroxyethylthio)-7H-pyrrolo<2,3-d>pyrimidin 
• 124-41-4 sodium methylate 
• 84955-31-7 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine 

Downstream Products

• 86781-82-0 2-amino-4-methoxy-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine 
• 86781-81-9 2-amino-4-methoxy-7-(2,3,5-tri-O-benzyl-α-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine 
• 115479-42-0 2-Amino-4-methoxy-7-β-D-ribofuranosylpyrrolo<2,3-d>pyrimidine 
• 101924-15-6 2-amino-7-<(1,3-dibenzyloxy-2-propoxy)methyl>pyrrolo<2,3-d>pyrimidin-4-one 
• 86392-75-8 7-deaza-2'-deoxyguanosine 
• 84955-38-4 2-amino-3,7-dihydro-7-<(2-hydroxyethoxy)-methyl>-4H-pyrrolo<2,3-d>pyrimidin-4-one 
• 81965-21-1 3,7-Dihydro-7-methyl-4H-pyrrolo<2,3-d>pyrimidin-4-on 
• 149765-28-6 diethyl N-<2-pivaloylamino-4-methoxy<(pyrrolo<2,3-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate 
• 149765-29-7 diethyl N-<2-pivaloylamino-4-methoxy<(pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate 
• 115945-78-3 2-amino-7-<2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-4-methoxy-7H-pyrrolo<2,3-d>pyrimidine 
• 101924-14-5 2-amino-4-methoxy-7-<(1,3-dibenzyloxy-2-propoxy)methyl>pyrrolo<2,3-d>pyrimidine 
• 131981-22-1 7-{5'-O-[(1,1-dimethylethyl)dimethylsilyl]-2',3'-O-(1-methylethylidene)-β-D-ribofuranosyl}-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine 

Relevant academic research and scientific papers

Compound with 2-aminopyrimidine structure as well as preparation method and purpose thereof

The invention provides a compound of a 2-aminopyrimidine structure shown as a general formula (1), or a stereisomer, enantiomers or medically acceptable salt of the compound, a preparation method of the compound, a medicine composition containing the composition or a purpose of the composition. The compound shown as the general formula (1) can be used for preparing NIK kinase inhibitors, and can be used for preventing and/or treating diseases relevant to NIK kinase, particularly cancer and metabolic diseases, such as B-cell dysfunction related cancer such as multiple myeloma, lymphocyte carcinoma, diffuse large B cell lymphoma of liver cancer, hodgkin lymphoma and chronic lymphocytic leukemia, prostatic cancer, liver cancer, intestinal cancer, medicine induced liver damage, alcohol inducedliver damage, toxic induced acute liver injury, chronic liver inflammation and the like. The general formula (1) is shown in the description.

THE SYNTHESIS OF N-PYRIMIDIN-5-YL)ETHYL>BENZOYL>-L-GLUTAMIC ACIDS AS ANTINEOPLASTIC AGENTS

A series of N-pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acids were synthesized.In this current synthesis, compound 2-amino-4-chloro-pyrrolopyrimidine (4) was selected as an important precursor for the preparation of key intermediates such as 5b, 10b, 15a and 15b.These highly functionalized pyrrolopyrimidines were then later coupled with either 4-ethynylbenzoylglutamate or 4-iodobenzoylglutamate in a palladium catalyzed Heck reaction and thus provided the basic skeleton of the targeted molecules.The availability ofthe chlorine atom at the 4-position of the pyrrolopyrimidine nucleus has allowed us to introduce different substituents at this position efficiently.By this approach, we were able to prepare a variety of 4-substituted pyrrolopyrimidine based folate antagonists (2a-2g) which are closely related to the novel thymidylate synthase inhibitor LY231514.In vitro analysis has demonstrated that some of these agents are highly cytotoxic against human leukemic cells (CCRF-CEM) in culture.

Synthesis of Acyclo-7-deazaguanosine by Regiospecific Phase-Transfer Alkylation of 2-Amino-4-methoxy-7H-pyrrolopyrimidine

Acyclo-7-deazaguanosine (2), a structural analogue of the antiviral highly active acycloguanosine (1), has been synthesized.Regiospecificity of the electrophilic attack was shown by phase-transfer methylation of 2-amino-4-methoxy-7H-pyrrolopyrimidi