131981-22-1

Basic information

• Product Name: 2-Amino-4-methoxyl-7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl--D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine
• Synonyms: 2-Amino-4-methoxyl-7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl--D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine;7-[5-O-[(1,1-Dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)- -D-ribofuranosyl]-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine;7-[5-O-[(1,1-Dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-2 -D-ribofuranosyl]-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine
• CAS NO: 131981-22-1
• Molecular Formula: C21H34N4O5Si
• Molecular Weight: 450.6
• Product Categories: Chiral Reagents;Heterocycles;Chiral Reagents, Heterocycles
• Mol File: 131981-22-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Refractive Index: 1.584
• Solubility: Dichloromethane, Methanol
• CAS DataBase Reference: 2-Amino-4-methoxyl-7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl--D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-methoxyl-7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl--D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine(131981-22-1)
• EPA Substance Registry System: 2-Amino-4-methoxyl-7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl--D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine(131981-22-1)

Safety Data

• Hazardous Substances Data: 131981-22-1(Hazardous Substances Data)

Usage

Description

2-Amino-4-methoxyl-7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl--D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine, with the chemical name 7-[5-O-[(1,1-Dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine (CAS# 131981-22-1), is a complex organic compound that plays a significant role in various applications due to its unique chemical structure and properties.

Uses

Used in Organic Synthesis:
2-Amino-4-methoxyl-7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl--D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine is used as a key intermediate in organic synthesis for the development of new pharmaceutical compounds and other organic molecules. Its unique structure allows for versatile chemical reactions, making it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Amino-4-methoxyl-7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl--D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine is used as a precursor for the synthesis of novel drug candidates. Its unique chemical properties enable the development of new therapeutic agents with potential applications in various medical fields.
Used in Chemical Research:
2-Amino-4-methoxyl-7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl--D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine is also utilized in chemical research to study the reactivity and properties of complex organic molecules. Its unique structure provides researchers with valuable insights into the behavior of similar compounds and contributes to the advancement of organic chemistry.

InChI:InChI=1/C21H34N4O5Si/c1-20(2,3)31(7,8)27-11-13-14-15(30-21(4,5)29-14)18(28-13)25-10-9-12-16(25)23-19(22)24-17(12)26-6/h9-10,13-15,18H,11H2,1-8H3,(H2,22,23,24)/t13-,14+,15+,18-/m1/s1

Upstream product

• 124-41-4 sodium methylate 
• 115479-40-8 4-chloro-7-{5′-O-[(1,1-dimethylethyl)-dimethylsilyl]-2′,3′-O-(1-methylethylidene)-β-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidine-2-amine 
• 102690-94-8 2,3-O-isopropylidene-5-O-(tert-butyldimethylsilyl)-α-D-ribofuranosyl chloride 
• 84955-32-8 2-amino-4-methoxy-7H-pyrrolo[2,3-d]-pyrimidine 

Downstream Products

• 115479-42-0 2-Amino-4-methoxy-7-β-D-ribofuranosylpyrrolo<2,3-d>pyrimidine 

Relevant articles and documents

Synthesis and structure-activity relationship of ribofuranosyl echiguanine analogs as inhibitors of phosphatidylinositol 4-kinase

N-Substituted-2-amino-4(3H)-7H-oxopyrrolo[2,3-d]pyrimidine-5- carboxamides and their ribofuranosyl and 2',3'-dideoxyribofuranosyl derivatives were prepared as membrane permeable echiguanine analogs and tested for their ability to inhibit phosphatidylinositol (PI) 4-kinase. Compounds 5 and 6 were found to inhibit the enzyme approximately at the same level as echiguanines A and B. It is noteworthy that ribofuranosides 18, 19, and 20 and dideoxyribofuranoside 29 effectively inhibited PI 4-kinase. Thus, the terminal amide and related structures may be preferable for inhibition of the enzyme in echiguanine analogs with or without ribofuranoside.

2,4-Disubstituted pyrrolo[2,3-d]pyrimidine α-D- and β-D-ribofuranosides related to 7-deazaguanosine

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