849671-39-2Relevant academic research and scientific papers
Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors
Tully, David C.,Liu, Hong,Chatterjee, Arnab K.,Alper, Phil B.,Williams, Jennifer A.,Roberts, Michael J.,Mutnick, Daniel,Woodmansee, David H.,Hollenbeck, Thomas,Gordon, Perry,Chang, Jonathan,Tuntland, Tove,Tumanut, Christine,Li, Jun,Harris, Jennifer L.,Karanewsky, Donald S.
, p. 5107 - 5111 (2007/10/03)
We report a novel series of noncovalent inhibitors of cathepsin S. The synthesis of the peptidomimetic scaffold is described and structure-activity relationships of P3, P1, and P1′ subunits are discussed. Lead optimization to a non-peptidic scaffold has r
COMPOUNDS AND COMPOSITIONS AS CATHEPSIN S INHIBITORS
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Page/Page column 24, (2010/02/14)
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.
INHIBITORS OF CATHEPSIN S
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Page/Page column 50, (2008/06/13)
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
INHIBITORS OF CATHEPSIN S
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Page/Page column 40, (2008/06/13)
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also
