84970-12-7Relevant academic research and scientific papers
Indoxyl-based umpolung strategy for the synthesis of unsymmetrical 3,3′-biindoles
Guo, Jing,Weng, Jiang,Huang, Gong-Bin,Huang, Lin-Jie,Chan, Albert S.C.,Lu, Gui
, p. 5493 - 5496 (2016/11/19)
3,3′-Bisindoles are known to be important structural motifs found in bioactive natural products, pharmaceuticals, and functional materials. Herein, a novel indoxyl-based approach was established for the synthesis of unsymmetrical 3,3′-biindoles from indoles and indoxyls. This approach generated moderate to excellent yields of the desired products (24 examples, up to 98% yield). The present method features broad substrate scope, operational simplicity, high atom economy, and utilization of non-toxic and inexpensive molecular iodine as catalyst. The applicability of this method has been demonstrated by the facile gram-scale synthesis.
The Ullmann coupling between 2-chlorobenzoic acids and amino acids; a valuable reaction for preparing 2-substituted 1-acetyl-1H-indol-3-yl acetates
Dominguez, Juan Carlos Rodriguez,Gang, Xiao,Kirsch, Gilbert
scheme or table, p. 2345 - 2348 (2010/01/15)
2-Substituted 3-acetoxy-1-acetyl-1H-indoles were prepared by condensing 2-chlorobenzoic acids with amino acids under Ullmann conditions in good yields, and further cyclodecarboxylation using the Roessing method in moderate to good yields. Georg Thieme Ver
