84978-80-3Relevant academic research and scientific papers
GPR52 MODULATOR COMPOUNDS
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, (2022/03/22)
The disclosures herein relate to novel compounds of Formula (1): or a salt thereof, wherein Q, V, L, W, R1 and R2 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.
GPR52 MODULATOR COMPOUNDS
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Page/Page column 54; 78-79, (2021/05/15)
The disclosures herein relate to novel compounds of Formula (1): (1) and salts thereof, wherein R1, Q, X, Y and Z are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.
Preparation and double Michael addition reactions of a synthetic equivalent of the Nazarov reagent
Amat, Mercedes,Arioli, Federica,Perez, Maria,Molins, Elies,Bosch, Joan
supporting information, p. 2470 - 2473 (2013/07/04)
A synthetic equivalent of the Nazarov reagent, the silyl derivative 2, able to undergo base-catalyzed double Michael addition reactions with α,β-unsaturated carbonyl compounds has been developed. The new reagent satisfactorily reacts with unsaturated indo
Synthesis of 3-(phosphorylmethyl)cycloalkenones by forced conjugate addition of α-phosphonate carbanions to cyclic enones
Mikolajczyk, Marian,Perlikowska, Wieslawa
, p. 1225 - 1229 (2008/02/02)
Cycloalkenones were found to react with α-lithiated diethyl (phenylselanyl)methylphosphonate preferentially or exclusively at the carbonyl group giving 1,2-adducts. When complexes of cycloalkenones with aluminum tris(2,6-diphenylphenoxide) were used for t
NaOH-Catalyzed Thiolysis of α,β-Epoxyketones in Water. A Key Step in the Synthesis of Target Molecules Starting from α,β -Unsaturated Ketones
Fringuelli, Francesco,Pizzo, Ferdinando,Vaccaro, Luigi
, p. 2315 - 2321 (2007/10/03)
NaOH (0.02-0.3 molar equiv) is an efficient catalyst for the thiolysis reactions of α,β-epoxy ketones with alkyl and aryl thiols in water. Thiolysis of 3,4-epoxyheptan-2-one (1) with thiols 2a-d has been accomplished in mild conditions (30 °C and pH 6 or
Cyclopentannulations Leading to the Synthesis of Bicyclic Conjugated Enediones
Yechezekel, Tamar,Ghera, Eugene,Ostercamp, Daryl,Hassner, Alfred
, p. 5135 - 5142 (2007/10/02)
Base-induced reactions of 1-(phenylsulfonyl)-2-methylene-3-bromopropane (4) with 2-(phenylsulfonyl)-2-cycloalkenones 8a-d were investigated with the ultimate purpose to develop a route leading to bicyclic conjugated enediones.Low-temperature, fast-quenche
