849795-72-8Relevant academic research and scientific papers
An efficient, PIFA mediated approach to benzo-, naphtho-, and heterocycle-fused pyrrolo[2,1-c][1,4]diazepines. An advantageous access to the antitumor antibiotic DC-81
Correa, Arkaitz,Tellitu, Imanol,Dominguez, Esther,Moreno, Isabel,SanMartin, Raul
, p. 2256 - 2264 (2007/10/03)
(Chemical Equation Presented) The synthesis of a series of optically pure benzo-, naphtho-, and heterocycle-fused pyrrolo[2,1-c][1,4]-diazepin-5,11-dione derivatives starting from L-proline methyl ester is presented. The synthetic plan includes an aroylat
A novel route to pyrrolo[2,1-c][1,4]benzodiazepin-5-ones. Formal total synthesis of (±)-DC-81
Wang, Tiansheng,Lui, Alfred S.,Cloudsdale, Ian S.
, p. 1835 - 1837 (2008/02/11)
(formula presented) Compounds 3a and 3b were synthesized from N-allylisatoic anhydrides 5a and 5b in six and seven steps, respectively. Synthesis of 3b constitutes a formal total synthesis of (±)-DC-81.
Novel biocatalytic reduction of aryl azides: Chemoenzymatic synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics
Kamal, Ahmed,Damayanthi,Reddy, B. S. Narayan,Lakminarayana,Reddy, B. S. Praveen
, p. 1015 - 1016 (2007/10/03)
The chemoselective reduction of aryl azides to aryl amines, and the synthesis of the imine-containing pyrrolo[2,1-c][1-4]benzodiazepine DNA-binding antitumour antibiotics by selective biocatalytic reductive cyclization of azido aldehydes, has been achieved by employing baker's yeast.
