84984-47-4Relevant articles and documents
Acylation de quelques olefines substituees selon Friedel-Crafts. Synthese de cetones insaturees encombrees
Dubois, Jacques-Emile,Saumtally, Imran,Lion, Claude
, p. 133 - 138 (2007/10/02)
The Friedel-Crafts acylation of olefins by acid chlorides has been carried out on very heavily substituted olefins.Coupled by catalytic hydrogenation this reaction allows, in principle, the synthesis of hindered saturated ketones.Compounds of the type tBuiPrCHCOCHiPr2 (2221) (2220) tBuiPrCHCOCHiPrtBu (2221) (2221) and tBu2CHCOCHiPrtBu (2222) (2221) which are impossible to obtain by other methods, become accessible.