849934-82-3

Usage

Uses

2-Ethoxy-3-(trifluoromethyl)pyridine

Upstream product

• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 
• 141-52-6 sodium ethanolate 
• 175205-82-0 2-bromo-3-(trifluoromethyl)-pyridine 

Downstream Products

• 1431541-40-0 {3-[6-(6-ethoxy-5-trifluoromethyl-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-(4-methyl-piperazin-1-yl)-methanone 

Relevant academic research and scientific papers

Method for preparing alkyl ethers and aryl ethers

Method for preparing compounds of the formula (III) by reacting compounds of the formula (II) with a) an alcoholate or b) an alcohol R1-OH and a base in the presence of a Cu-containing catalyst and of a ligand, where X1-5 are independently of one another either carbon or nitrogen, or in each case two adjacent X1R1, with i=1?6, linked by a formal double bond together O, S, NRH or Nrl. The ligands preferably employed are acyclic and/or cyclic oligo- and polyglycols, oligo- and polyamides or oligo- and polyamine glycols of the general formula (IV) k is an integer >0 and n is an integer >1; X and Y are independently of one another O, NH or NR1.

Modulators of LXR

Compounds of the invention, such as compounds of formula (I): where n, m, A, B, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.