85-90-5

Basic information

• Product Name: 3-METHYLCHROMONE
• Synonyms: 3-methyl-4h-1-benzopyran-4-on;3-methyl-4h-1-benzopyran-4-one;3-methyl-chromon;3-metil-cromone;crodimyl;cromonalgina;diacromone;spasmocromona
• CAS NO: 85-90-5
• Molecular Formula: C₁₀H₈O₂
• Molecular Weight: 160.17
• EINECS: 201-641-0
• Mol File: 85-90-5.mol
• Article Data: 17

Chemical Properties

• Melting Point: 68°
• Boiling Point: 246.06°C (rough estimate)
• Flash Point: 108.6°C
• Appearance: /
• Density: 1.0924 (rough estimate)
• Vapor Pressure: 0.0228mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• CAS DataBase Reference: 3-METHYLCHROMONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLCHROMONE(85-90-5)
• EPA Substance Registry System: 3-METHYLCHROMONE(85-90-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 85-90-5(Hazardous Substances Data)

Usage

General Description

3-Methylchromone is a chemical compound that belongs to the chromone class of organic compounds. It is a derivative of chromone, which is a naturally occurring compound found in a variety of plants. 3-Methylchromone is known for its potential pharmacological properties, including its use as an anti-inflammatory and anti-cancer agent. It has shown promise in preclinical studies for its ability to inhibit inflammation and tumor growth. Additionally, it has been investigated for its antioxidant and neuroprotective properties, making it a compound of interest for potential therapeutic applications. Overall, 3-Methylchromone represents a class of compounds with diverse biological activities and potential for pharmaceutical development.

InChI:InChI=1/C10H8O2/c1-7-6-12-9-5-3-2-4-8(9)10(7)11/h2-6H,1H3

Upstream product

• 104094-15-7 3-methyl-4-oxo-4H-chromene-2-carboxylic acid 
• 611-20-1 salicylonitrile 
• 868732-17-6 3-methyl-2-(methylthio)-4H-chromen-4-one 
• 28752-82-1 2-(allyloxy)benzaldehyde 
• 2985-33-3 monoethyl methylmalonate 
• 90-02-8 salicylaldehyde 
• 123-54-6 acetylacetone 
• 16982-86-8 3-methyl-chroman-4-one 
• 106129-86-6 1-(2-hydroxyphenyl)-3-dimethylaminoprop-2-enone 
• 74-88-4 methyl iodide 
• 610-99-1 1-(2-Hydroxy-phenyl)-propan-1-on 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 29978-83-4 o-propargyloxybenzaldehyde 
• 153933-58-5 o-(1,2-propanedienyloxy)benzaldehyde 

Downstream Products

• 118450-20-7 3-(2-hydroxyphenyl)-4-methyl-1-thicarbamyl-5-thiosemicarbazide-2-pyrazoline 
• 67363-57-9 4-methyl-5-(o-hydroxyphenyl)-isoxazole 
• 89047-15-4 2-amino-3-methyl-4H-chromen-4-one 
• 16982-86-8 3-methyl-chroman-4-one 
• 15058-15-8 2-(2-methyl-4H-1-benzopyran-4-ylidene)propanedinitrile 
• 20924-67-8 2-(hydroxydiphenylmethyl)-3-methyl-4H-chromen-4-one 
• 1334228-63-5 2-diphenylmethyl-3-methylchromen-4-one 

Relevant articles and documents

Relay Catalysis by Achiral Borane and Chiral Phosphoric Acid in the Metal-Free Asymmetric Hydrogenation of Chromones

A strategy of relay catalysis by achiral borane and chiral phosphoric acid was successfully developed for the asymmetric hydrogenation of chromones, giving the desired products in high yields with up to 95% ee. Achiral borane and chiral phosphoric acid are highly compatible in this reaction. The achiral borane acts as a Lewis acid for the first-step hydrogenation, and the chiral phosphoric acid acts as an effective chiral proton shuttle to control the enantioselectivity.

The magnetic graphene oxide/NHC catalyzed aerobic direct amidation and cross-dehydrogenative coupling of aldehydes

In this paper, the synthesis of a novel imidazolium based N-heterocyclic carbene (NHC) containing imidazopyridine substitutes using a three-component reaction is described. This compound was immobilized on magnetic graphene oxide (GO) to make a heterogeneous catalyst for the direct aerobic amidation of benzaldehyde derivatives under solvent-free conditions, as well as the intra-and intermolecular cross dehydrogenative coupling of aldehydes. In addition, the catalytic activity of the NHC catalyst was homogeneously studied in the presence of Fe3O4 nanoparticles under the same conditions, and showed good activity with lower yields than the heterogeneous catalyst.

Synthesis of Enones and Enals via Dehydrogenation of Saturated Ketones and Aldehydes

A general, efficient and economic palladium-catalyzed dehydrogenation to form enones or enals has been developed. The approach possesses extremely broad substrate scope including various linear or cyclic saturated ketones and aldehydes. The protocol is ligand-free, and molecular oxygen is used as the sole clean oxidant in the reaction. Due to mild reaction conditions, good functional group compatibility, and versatile utilities of enones and enals, the method can be applied in the late-stage synthesis of natural products, pharmaceuticals and fine chemicals. (Figure presented.).