89296-04-8Relevant academic research and scientific papers
Novel Bicyclic Pyridinones
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Page/Page column 69, (2012/10/08)
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
α1-Adrenoceptor agonists: The identification of novel α1A subtype selective 2′-heteroaryl-2-(phenoxymethyl)imidazolines
Bishop, Michael J.,Barvian, Kevin A.,Berman, Judd,Bigham, Eric C.,Garrison, Deanna T.,Gobel, Michael J.,Hodson, Stephen J.,Irving, Paul E.,Liacos, James A.,Navas, Iii, Frank,Saussy Jr., David L.,Speake, Jason D.
, p. 471 - 475 (2007/10/03)
Novel 2′-heteroaryl-2-(phenoxymethyl)imidazolines have been identified as potent agonists of the cloned human α1-adrenoceptors in vitro. The nature of the 2′-heteroaryl group can have significant effects on the potency, efficacy, and subtype selectivity in this series. α1A Subtype selective agonists have been identified.
The Reaction of S,S-Diphenylsulphilimine with Benzopyran-4-ones and Benzopyran-4-thiones
Buggle, Katherine,Fallon, Bernadette
, p. 2764 - 2784 (2007/10/02)
Benzopyran-4-ones unsubstituted at carbons 2 and 3 yield aziridines, amines and isoxazoles on treatment with diphenylsulphilimine.The product composition is temperature dependent, aziridines being the major products at room temperature and amines at highe
