850011-53-9

Basic information

• Product Name: Benzenepropanoic acid, b-(formylamino)-, ethyl ester
• CAS NO: 850011-53-9
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Mol File: 850011-53-9.mol

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, b-(formylamino)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, b-(formylamino)-, ethyl ester(850011-53-9)
• EPA Substance Registry System: Benzenepropanoic acid, b-(formylamino)-, ethyl ester(850011-53-9)

Safety Data

• Hazardous Substances Data: 850011-53-9(Hazardous Substances Data)

Upstream product

• 37643-54-2 N-[(4-methylbenzene-1-sulfonyl)(phenyl)methyl]formamide 
• 2678-54-8 ketene diethyl acetal 

Downstream Products

• 614-19-7 (R)-3-phenyl-3-aminopropionic acid 
• 614-19-7 (S)-3-amino-3-phenylpropanoic acid 
• 3082-67-5 L-3-(N-formylamino)-3-phenylpropionic acid 
• 40856-45-9 D-3-(N-formylamino)-3-phenylpropionic acid 
• 869070-91-7 3-{5-[benzylamino-(4-tert-butoxycarbonylamino-phenyl)-methyl]-tetrazol-1-yl}-3-phenyl-propionic acid ethyl ester 
• 869070-96-2 3-{5-[1-(benzhydryl-amino)-2-methyl-propyl]-tetrazol-1-yl}-3-phenyl-propionic acid ethyl ester 
• 869070-94-0 3-{5-[(2,2-dimethoxy-ethylamino)-(4-methoxy-phenyl)-methyl]-tetrazol-1-yl}-3-phenyl-propionic acid ethyl ester 
• 869070-95-1 4-{1-[1-(2-ethoxycarbonyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-2-methyl-propylamino}-benzoic acid methyl ester 
• 869070-87-1 3-[5-(1-benzylamino-2-methyl-propyl)-tetrazol-1-yl]-3-phenyl-propionic acid ethyl ester 

Relevant articles and documents

A new synthesis of β-amino acids by use of ketene diethyl acetal as enolate equivalent

Reaction of phenylsulfonyl formamides, readily available in a single step from an aromatic aldehyde and sodium phenylsulfinate, with ketene diethyl acetal under basic conditions gives N-formyl β-amino acid esters in good yield, which can be kinetically resolved with a lipase.

PROCESS FOR THE PREPARATION OF β-AMINOCARBOXYLIC ACIDS

The present invention relates to a method of producing β-aminocarboxylic acids or their derivatives by conversion of compounds of formula (I) with ketene acetals in the presence of a base.