850072-65-0

Basic information

• Product Name: ethyl 6-(hydroxymethyl)benzothiophene-2-carboxylate
• Synonyms: ethyl 6-(hydroxymethyl)-1-benzothiophene-2-carboxylate; Ethyl-6-(hydroxymethyl)-1-benzothiophen-2-carboxylat
• CAS NO: 850072-65-0
• Molecular Formula: C₁₂H₁₂O₃S
• Molecular Weight: 236.29
• Mol File: 850072-65-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 402.1°C at 760 mmHg
• Flash Point: 197°C
• Density: 1.303g/cm³
• Vapor Pressure: 3.46E-07mmHg at 25°C
• Refractive Index: 1.64
• CAS DataBase Reference: ethyl 6-(hydroxymethyl)benzothiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6-(hydroxymethyl)benzothiophene-2-carboxylate(850072-65-0)
• EPA Substance Registry System: ethyl 6-(hydroxymethyl)benzothiophene-2-carboxylate(850072-65-0)

Safety Data

• Hazardous Substances Data: 850072-65-0(Hazardous Substances Data)

Upstream product

• 850074-43-0 benzo[b]thiophene-2,6-dicarboxylic acid 2-ethyl ester 
• 850074-44-1 6-formyI-benzo[b]thiophene-2-carboxylic acid ethyl ester 
• 104447-80-5 (E)-1-(dimethylamino)-2-[4-(methoxycarbonyl)-2-nitrophenyl]ethene 
• 7356-11-8 4-methyl-3-nitro-benzoic acid methyl ester 
• 850074-42-9 2-ethyl 6-methyl benzo[b]thiophene-2,6-dicarboxylate 
• 153813-69-5 methyl 4-formyl-3-nitrobenzoate 

Downstream Products

• 850074-44-1 6-formyI-benzo[b]thiophene-2-carboxylic acid ethyl ester 
• 947513-35-1 C₁₈H₁₇NSO₂ 
• 850074-74-7 6-(benzylamino-methyl)-benzo[b]thiophene-2-carboxylic acid ethyl ester 
• 947513-38-4 C₂₀H₂₁NSO₂ 
• 102636-02-2 6-hydroxymethyl-benzo[b]thiophene-2-carboxylic acid 
• 850072-66-1 6-hydroxymethyl-benzo[b]thiophene-2-carboxylic acid methyl ester 
• 850074-77-0 6-benzyloxymethyl-benzo[b]thiophene-2-carboxylic acid hydroxyamide 
• 850072-64-9 6-aminomethylbenzo[b]thiophene-2-carboxylic acid ethyl ester, hydrochloride salt 
• 850074-68-9 6-[(4-methoxy-benzylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid ethyl ester 
• 913739-27-2 C₂₅H₂₉N₃O₃S 

Relevant articles and documents

ORTHO AMINOAMIDES FOR THE TREATMENT OF CANCER

Compounds of formula are HDAC inhibitors. These compounds are useful for the treatment of diseases such as cancer in humans or animals.

HYDROXAMIC ACID DERVICATIVES AS INHIBITORS OF HDAC ENZYMATIC ACTIVITY

Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers: formula (I) wherein Y1 is a bond, -(C=O)-, -S(O2)-, -C(=O)O-, -OC(=O)-, -(C=O)NR3, -NR3(C=O)-, -S(O2)NR3-, -NR3S(O2)-, or -NR3(C=O)NR5-, wherein R3 and R5 are independently hydrogen or optionally substituted (C1-C6)alkyl, L1 is a divalent radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n, p, AIk1, AIk2 and Q are as defined in the claims; z is O or 1 ; A represents an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; -[Linker]- represents a divalent linker radical; R is a radical of formula (X) or (Y); wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, heteroaryl(C1-C6 alkyl)-, -(C=O)R3, -(C=O)OR3, or -(C=O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, or heteroary(C1-C6 alkyl)-; R41 is hydrogen or optionally substituted C1-C6 alkyl; and B is a monocyclic heterocyclic ring of 5 or 6 ring atoms wherein R1 is linked to a ring carbon adjacent the ring nitrogen shown, and ring B is optionally fused to a second carbocyclic or heterocyclic ring of 5 or 6 ring atoms in which case the bond shown intersected by a wavy line may be from a ring atom in said second ring.

BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES

The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing t