914645-85-5

Basic information

• Product Name: 2-(S)-tert-butoxycarbonylamino-3-{4-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-phenoxy]-cyclohexyl}-propionic acid cyclopentyl ester
• Synonyms: 2-(S)-tert-butoxycarbonylamino-3-{4-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-phenoxy]-cyclohexyl}-propionic acid cyclopentyl ester
• CAS NO: 914645-85-5
• Molecular Weight: 766.012
• Mol File: 914645-85-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(S)-tert-butoxycarbonylamino-3-{4-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-phenoxy]-cyclohexyl}-propionic acid cyclopentyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(S)-tert-butoxycarbonylamino-3-{4-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-phenoxy]-cyclohexyl}-propionic acid cyclopentyl ester(914645-85-5)
• EPA Substance Registry System: 2-(S)-tert-butoxycarbonylamino-3-{4-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-phenoxy]-cyclohexyl}-propionic acid cyclopentyl ester(914645-85-5)

Safety Data

• Hazardous Substances Data: 914645-85-5(Hazardous Substances Data)

Upstream product

• 153813-69-5 methyl 4-formyl-3-nitrobenzoate 
• 102636-02-2 6-hydroxymethyl-benzo[b]thiophene-2-carboxylic acid 
• 75383-60-7 (4-hydroxy-benzyl)carbamic acid benzyl ester 
• 104447-80-5 (E)-1-(dimethylamino)-2-[4-(methoxycarbonyl)-2-nitrophenyl]ethene 
• 696-60-6 4-aminomethylphenol 
• 7356-11-8 4-methyl-3-nitro-benzoic acid methyl ester 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 914452-24-7 6-hydroxymethyl-benzo[b]thiophene-2-carboxylic acid (1-isobutoxy-ethoxy) amide 
• 914645-83-3 3-{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-cyclohexyl}-2-(S)-tert-butoxycarbonylamino-propionic acid cyclopentyl ester 
• 914452-22-5 (S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid cyclopentyl ester 
• 914645-82-2 2(S)-tert-butoxycarbonylamino-3-(4-hydroxy-cyclohexyl)-propionic acid cyclopentyl ester 
• 914452-23-6 (S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid cyclopentyl ester 
• 850072-65-0 6-hydroxymethyl-benzo[b]thiophene-2-carboxylic acid ethyl ester 
• 850074-43-0 benzo[b]thiophene-2,6-dicarboxylic acid 2-ethyl ester 

Relevant articles and documents

HYDROXAMIC ACID DERVICATIVES AS INHIBITORS OF HDAC ENZYMATIC ACTIVITY

Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers: formula (I) wherein Y1 is a bond, -(C=O)-, -S(O2)-, -C(=O)O-, -OC(=O)-, -(C=O)NR3, -NR3(C=O)-, -S(O2)NR3-, -NR3S(O2)-, or -NR3(C=O)NR5-, wherein R3 and R5 are independently hydrogen or optionally substituted (C1-C6)alkyl, L1 is a divalent radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n, p, AIk1, AIk2 and Q are as defined in the claims; z is O or 1 ; A represents an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; -[Linker]- represents a divalent linker radical; R is a radical of formula (X) or (Y); wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, heteroaryl(C1-C6 alkyl)-, -(C=O)R3, -(C=O)OR3, or -(C=O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, or heteroary(C1-C6 alkyl)-; R41 is hydrogen or optionally substituted C1-C6 alkyl; and B is a monocyclic heterocyclic ring of 5 or 6 ring atoms wherein R1 is linked to a ring carbon adjacent the ring nitrogen shown, and ring B is optionally fused to a second carbocyclic or heterocyclic ring of 5 or 6 ring atoms in which case the bond shown intersected by a wavy line may be from a ring atom in said second ring.