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CAS

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850090-09-4

HO-PEG5-tBu is a PEGylated crosslinker that consists of a hydrophilic PEG spacer with a hydroxyl group at one end and a t-butyl-protected carboxylic acid at the other. The hydroxyl group allows for further derivatization or replacement with other reactive functional groups, while the t-butyl protected carboxyl group can be deprotected under acidic conditions. This heterobifunctional linker enhances solubility in aqueous media and is useful for various applications in chemical biology and medicinal chemistry.

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  • 2-Methyl-2-propanyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oa te

    Cas No: 850090-09-4

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  • 850090-09-4 Structure

  • Basic information

    1. Product Name: HO-PEG5-tBu
    2. Synonyms: 1-Hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oic acid 1,1-dimethylethyl ester;HO-PEG5-CH2CH2COOtBu;HO-PEG5-CH2CH2COOtBu;Hydroxy-PEG5-CH2CO2tBu;Hydroxy-PEG5-t-butly ester;HO-PEG5-tBu;OH-PEG5-CH2CH2COOtBu
    3. CAS NO:850090-09-4
    4. Molecular Formula: C17H34O8
    5. Molecular Weight: 366.44706
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 850090-09-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 445.4±40.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.071
    6. Refractive Index: n/D 1.448
    7. Storage Temp.: -20°C
    8. Solubility: N/A
    9. PKA: 14.36±0.10(Predicted)
    10. CAS DataBase Reference: HO-PEG5-tBu(CAS DataBase Reference)
    11. NIST Chemistry Reference: HO-PEG5-tBu(850090-09-4)
    12. EPA Substance Registry System: HO-PEG5-tBu(850090-09-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 850090-09-4(Hazardous Substances Data)

850090-09-4 Usage

Uses

Used in Bioconjugation:
HO-PEG5-tBu is used as a crosslinker for bioconjugation, enabling the attachment of small molecules or biomolecules to form conjugates or other tool compounds. The hydrophilic PEG linker facilitates solubility in biological applications.
Used in Chemical Biology and Medicinal Chemistry:
HO-PEG5-tBu is used as a building block for the synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds that require ligation in chemical biology and medicinal chemistry.
Used in Antibody-Drug Conjugates:
HO-PEG5-tBu is used as a linker in the synthetic incorporation of antibody-drug conjugates, allowing for the attachment of therapeutic agents to antibodies for targeted delivery.
Used in Proteolysis-Targeting Chimeras (PROTACs):
HO-PEG5-tBu is used as a component in the design and synthesis of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation, enabling the development of novel therapeutic strategies.

Check Digit Verification of cas no

The CAS Registry Mumber 850090-09-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,0,0,9 and 0 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 850090-09:
(8*8)+(7*5)+(6*0)+(5*0)+(4*9)+(3*0)+(2*0)+(1*9)=144
144 % 10 = 4
So 850090-09-4 is a valid CAS Registry Number.

850090-09-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Methyl-2-propanyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oa te

1.2 Other means of identification

Product number -
Other names 18-Hydroxy-19-norcorticosterone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:850090-09-4 SDS

850090-09-4Relevant articles and documents

Conjugate and preparation method and application thereof

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Paragraph 0078; 0082-0089, (2021/08/28)

The invention relates to the technical field of biology, and discloses a conjugate and a preparation method and application thereof. The conjugate is formed by covalent attachment of a nitrogen-azide modified targeting ligand and a propargyl-modified smal

Synthesis of KUE-siRNA Conjugates for Prostate Cancer Cell-Targeted Gene Silencing

Yang, Chao,Ma, Dejun,Lu, Liqing,Yang, Xing,Xi, Zhen

, p. 2888 - 2895 (2021/08/03)

The delivery of siRNAs to selectively target cells poses a great challenge in RNAi-based cancer therapy. The lack of suitable cell-targeting methods seriously restricts the advance in delivering siRNAs to extrahepatic tissues. Based on prostate-specific m

Synthesis and application of poly(phenylene ethynylene)s for bioconjugation: A conjugated polymer-based fluorogenic probe for proteases

Wosnick, Jordan H.,Mello, Charlene M.,Swager, Timothy M.

, p. 3400 - 3405 (2007/10/03)

A set of carboxylate-functionalized poly(phenylene ethynylene)s (PPEs) has been synthesized in which the carboxylic acid groups are separated from the polymer backbone by oligo(ethylene glycol) spacer units. These polymers are soluble in water and organic

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