85012-73-3

Usage

Uses

Used in Pharmaceutical Synthesis:
1H-Imidazole-5-carboxaldehyde, 1-methyl-4-nitro(9CI) is used as a key building block for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of a wide range of organic compounds with potential therapeutic applications.
Used in Organic Synthesis:
1H-Imidazole-5-carboxaldehyde, 1-methyl-4-nitro(9CI) is employed as a versatile reagent in the synthesis of complex organic molecules, contributing to the development of new chemical entities with potential uses in various industries.
Used in Biochemical Assays:
1H-Imidazole-5-carboxaldehyde, 1-methyl-4-nitro(9CI) is used as a reagent in biochemical assays, facilitating the study of biological processes and the development of new diagnostic tools.
Used in Antimicrobial Applications:
1H-Imidazole-5-carboxaldehyde, 1-methyl-4-nitro(9CI) has been studied for its antimicrobial properties, making it a potential candidate for use in the development of new antimicrobial agents to combat drug-resistant infections.
Used in Anti-inflammatory Applications:
1H-Imidazole-5-carboxaldehyde, 1-methyl-4-nitro(9CI) has also been investigated for its anti-inflammatory properties, suggesting its potential use in the development of new treatments for inflammatory conditions.

Upstream product

• 38993-84-9 (1-methyl-1H-imidazol-5-yl)methanol 
• 143122-18-3 5-hydroxymethyl-2-mercapto-1-methyl-1H-imidazole 
• 85012-71-1 5-hydroxymethyl-1-methyl-4-nitro-1H-imidazole 
• 161091-88-9 5-dichloromethyl-1-methyl-4-nitroimidazole 
• 105557-98-0 C₄H₂N₃O₃^(1-)*Ag⁽¹⁺⁾ 
• 74-88-4 methyl iodide 

Downstream Products

• 960064-19-1 C₁₃H₈ClN₃O₄ 
• 960064-24-8 C₁₃H₈ClN₃O₄ 

Relevant academic research and scientific papers

Synthesis and calcium channel antagonist activity of 1,4-dihydropyridine derivatives containing 4-nitroimidazolyl substituents

Alkyl, cycloalkyl and arylalkyl ester analogues of nifedipine (CAS 21829-25-4), in which the ortho-nitro phenyl group at position 4 is replaced by 1-methyl-4-nitro-5-imidazolyl substituent, were synthesized and evaluated as calcium channel antagonists usi

Synthesis and Antihypertensive Activities of New 1,4-Dihydropyridine Containing Nitroimidazolyl Substituent with a Nitrooxy Group at the 3-Ester Position

New analogues of nifedipine, in which the ortho nitrophenyl group of position 4 is replaced by 1-methyl-4-nitro-5-imidazolyl or 1-methyl-5-imidazolyl with a nitrooxy group at the 3-ester position were synthesized, and the antihypertensive activity of the compounds was examined by the tail-cuff method and compared with TNG and nifedipine. Compounds 11g, 11i-m, 11o, 11r, and 11v showed activity similar to nifedipine and TNG.

Synthesis of Some New Imidazole Derivatives

N-Protected (CH2Ph, CH3) 4-nitroimidazoles (1) react with carbanions of tert-butyl chloroacetate, chloroacetonitrile and chloroform, affording Vicarious Nucleophilic Substitution of Hydrogen (VNS) products 2, 3, and 7, respectively.These compounds, after

4,5-DISUBSTITUTED IMIDAZOLES. PART I. 4-HYDROXYMETHYL-5-NITROIMIDAZOLE, 4-FORMYL-5-NITROIMIDAZOLE AND THEIR N-SUBSTITUTED DERIVATIVES

A synthesis of 4-hydroxymethyl-5-nitroimidazole, 4-formyl-5-nitroimidazole, their N-methyl and N-trityl derivatives were developed starting from easily accessible 4-hydroxymethylimidazole.The structures of N-substituted derivatives have been assumed on the basis of analyzing the 1H NMR data.