850146-73-5Relevant academic research and scientific papers
Synthesis of 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent
Srivastava, Vandana,Negi, Arvind S.,Kumar,Faridi, Uzma,Sisodia, Brijesh S.,Darokar,Luqman, Suaib,Khanuja
, p. 911 - 914 (2007/10/03)
3′,4′,5′-Trimethoxy benzoyl-naphthalene 2-O-acetic acid (5) underwent base catalysed intramolecular condensation to yield exclusively 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1-b]furan 8. The cyclised product 8 has been characterised by spectroscopy. The
Synthesis of gallic acid based naphthophenone fatty acid amides as cathepsin D inhibitors
Srivastava, Vandana,Saxena, Hari Om,Shanker, Karuna,Kumar,Luqman, Suaib,Gupta,Khanuja,Negi, Arvind S.
, p. 4603 - 4608 (2007/10/03)
Gallic acid, one of the most abundant plant phenolic acids, has been modified to cathepsin D protease inhibitors. The strategy of modification was proposed basing on some previously reported structure and activity relationship (SAR) studies. The synthesized naphthophenone fatty acid amide derivatives have been evaluated for in vitro cathepsin D inhibition activity. Two of them have shown significant inhibition activity with IC50 values of 0.06 and 0.14 μM, respectively, as compared against pepstatin (0.0023 μM), the most potent inhibitor known so far. The study revealed that such attempts on gallic acid based pharmacophores might result in potent inhibitors of cathepsin D.
