848851-59-2

Upstream product

• 1334232-95-9 C₂₄H₂₇NO₄ 
• 457923-29-4 1-naphthyl 3,4,5-trimethoxybenzoate 
• 135-19-3 β-naphthol 
• 118-41-2 Eudesmic acid 
• 457923-26-1 3,4,5-trimethoxybenzoic acid naphthalene-2-yl ester 
• 93-04-9 2-Methoxynaphthalene 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 

Downstream Products

• 910296-60-5 4-[1-(3,4,5-trimethoxybenzyl)-naphtalen-2-yloxy]-but-2-enoic acid 
• 850146-73-5 1-(3',4',5'-trimethoxybenzoyl)naphthalene 2-O-acetic acid 
• 848851-61-6 [1-(3,4,5-trimethoxy-benzoyl)-naphthalen-2-yloxy]-acetic acid ethyl ester 
• 857410-88-9 (3',4',5'-trimethoxyphenyl)-(1-naphthyl-2-(O-4''-ethyl-but-2''-enoate))methanone 

Relevant academic research and scientific papers

Cu/Ag mediated peroxide-free synthesis of benzoylated naphthol derivatives

A peroxide-free methodology was developed for the synthesis of benzoylated naphthol/phenol derivatives through oxidative deamination reaction performed under aerobic reaction conditions. A synergistic combination of Cu(OTf)2 and Ag2O was used to convert the aminonaphthols and aminophenols to the corresponding benzoylated derivatives. The definite role of atmospheric oxygen to assist the reaction was proved by performing the reaction in the argon atmosphere.

Synthesis of gallic acid based naphthophenone fatty acid amides as cathepsin D inhibitors

Gallic acid, one of the most abundant plant phenolic acids, has been modified to cathepsin D protease inhibitors. The strategy of modification was proposed basing on some previously reported structure and activity relationship (SAR) studies. The synthesized naphthophenone fatty acid amide derivatives have been evaluated for in vitro cathepsin D inhibition activity. Two of them have shown significant inhibition activity with IC50 values of 0.06 and 0.14 μM, respectively, as compared against pepstatin (0.0023 μM), the most potent inhibitor known so far. The study revealed that such attempts on gallic acid based pharmacophores might result in potent inhibitors of cathepsin D.

Synthesis of 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent

3′,4′,5′-Trimethoxy benzoyl-naphthalene 2-O-acetic acid (5) underwent base catalysed intramolecular condensation to yield exclusively 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1-b]furan 8. The cyclised product 8 has been characterised by spectroscopy. The

GALLIC ACID DERIVATIVE AND PROCESS OF PREPARING THE SAME

This invention provides a plant growth regulatory activity of a new biologically active synthetic molecule Methanone- (3', 4', 5'-trimethoxy) phenyl, 1-naphthyl, 2-O-4"-ethyl but-2"-enoate. More particularly, the invention relates to the potent plant growth promoting activity of a gallic acid derivative having the structural formulae (1) and molecular formulae C26H26O7. This invention also provides a novel process for preparation of a said molecule from a naturally occurring compound and testing it for growth regulating activity using Bacopa test system developed at CIMAP (Khanuja et al 2001).

Synthesis of a novel plant growth promoter from gallic acid

Gallic acid has been modified to naphthophenone derivatives with esterified fatty acid side chain. Compound 12, an ethyl crotonate ester of naphthophenone derivative has shown potent auxin like growth promoter activity. This is the first example of naphthophenone derivatives with plant growth promoting activity.