85017-61-4

Basic information

• Product Name: (2E)-3-(4-PENTYLPHENYL)PROP-2-ENOIC ACID
• Synonyms: (2E)-3-(4-PENTYLPHENYL)PROP-2-ENOIC ACID
• CAS NO: 85017-61-4
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.29152
• Mol File: 85017-61-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2E)-3-(4-PENTYLPHENYL)PROP-2-ENOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(4-PENTYLPHENYL)PROP-2-ENOIC ACID(85017-61-4)
• EPA Substance Registry System: (2E)-3-(4-PENTYLPHENYL)PROP-2-ENOIC ACID(85017-61-4)

Safety Data

• Hazardous Substances Data: 85017-61-4(Hazardous Substances Data)

Usage

General Description

(2E)-3-(4-PENTYLPHENYL)PROP-2-ENOIC ACID is a chemical compound with the molecular formula C15H18O2. It belongs to the class of compounds known as phenylpropanoids and is commonly found in essential oils and plant extracts. (2E)-3-(4-PENTYLPHENYL)PROP-2-ENOIC ACID has been studied for its potential anti-inflammatory and analgesic properties, making it a potential candidate for pharmaceutical applications. Additionally, it has been shown to have antioxidant and anticancer properties in some studies. Its structure consists of a phenyl ring attached to a prop-2-enoic acid moiety, with a pentyl side chain. Overall, (2E)-3-(4-PENTYLPHENYL)PROP-2-ENOIC ACID demonstrates diverse biological activities that make it a promising candidate for further research and potential therapeutic development.

Upstream product

• 141-82-2 malonic acid 
• 6853-57-2 4-pentylbenzaldehyde 
• 85017-60-3 4-iodine-pentyl benzene 
• 538-68-1 pentylbenzene 

Downstream Products

• 110683-10-8 ACA 
• 110683-13-1 (E)-N-(2-Cyanomethoxy-phenyl)-3-(4-pentyl-phenyl)-acrylamide 
• 110683-14-2 {2-[(E)-3-(4-Pentyl-phenyl)-acryloylamino]-phenoxy}-acetic acid 
• 110683-12-0 {2-[(E)-3-(4-Pentyl-phenyl)-acryloylamino]-phenoxy}-acetic acid ethyl ester 
• 110683-15-3 (E)-3-(4-Pentyl-phenyl)-N-[2-(1H-tetrazol-5-ylmethoxy)-phenyl]-acrylamide 

Relevant articles and documents

The Discovery of Novel ACA Derivatives as Specific TRPM2 Inhibitors that Reduce Ischemic Injury Both in Vitro and in Vivo

The transient receptor potential melastatin 2 (TRPM2) channel is associated with ischemia/reperfusion injury, inflammation, cancer, and neurodegenerative diseases. However, the limit of specific inhibitors impedes the development of TRPM2-targeted therapeutic agents. To discover more potent and selective TRPM2 inhibitors, 59 N-(p-amylcinnamoyl) anthranilic acid (ACA) derivatives were synthesized and evaluated using calcium imaging and electrophysiology approaches. Systematic structure-activity relationship studies resulted in some potent compounds inhibiting the TRPM2 channel with sub-micromolar half-maximal inhibitory concentration values. Among them, the preferred compound A23 exhibited TRPM2 selectivity over TRPM8 and TRPV1 channels as well as phospholipase A2 and showed neuroprotective activity in vitro. Following pharmacokinetic studies, A23 was further evaluated in a transient middle cerebral artery occlusion model in vivo, which significantly reduced cerebral infarction. These data indicate that A23 might serve as a useful tool for TRPM2-related research as well as a lead compound for the development of therapeutic agents for ischemic injury.

SYNTHESIS AND SOME TRANSFORMATIONS OF BENZOTHIOPHENE DERIVATIVES

A number of 3-chloro-2-chlorocarbonylbenzothiophenes with alkyl substituents in various positions of the benzene ring were synthesized by arylation of acrylic acid with the corresponding alkyl-substituted iodobenzenes under the influence of catalytic amounts of palladium acetate and subsequent oxidation of the resulting arylacrylic acids with thionyl chloride.Replacement of the pyridine added in the oxidation reaction by triethylbenzylammonium chloride led to substantial increases in the yields of the desired products.The possibility of conversionof the resulting benzothiophene derivatives to thiophene ring-unsubstituted benzothiophenes was shown in the case of 3-chloro-2-chlorocarbonylbenzothiophene as a result of successive saponification of the 2-chlorocarbonyl group, decarboxylation, and dechlorination.