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110683-10-8

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110683-10-8 Usage

Uses

N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively). It is a weak inhibitor of TRPV1. ACA is also an inhibitor of phospholipase A2, blocking the release of arachidonic acid when given at 50 μM.

references

harteneck c, frenzel h, kraft r. n-(p-amylcinnamoyl)anthranilic acid (aca): a phospholipase a(2) inhibitor and trp channel blocker. cardiovasc drug rev. 2007 spring;25(1):61-75.kraft r, grimm c, frenzel h, et al. inhibition of trpm2 cation channels by n-(p-amylcinnamoyl)anthranilic acid. br j pharmacol. 2006 jun;148(3):264-73.gwanyanya a, macianskiene r, bito v, et al. inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by n-(p-amylcinnamoyl)anthranilic acid (aca). biochem biophys res commun. 2010 nov 19;402(3):531-6.

Check Digit Verification of cas no

The CAS Registry Mumber 110683-10-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,6,8 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 110683-10:
(8*1)+(7*1)+(6*0)+(5*6)+(4*8)+(3*3)+(2*1)+(1*0)=88
88 % 10 = 8
So 110683-10-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+

110683-10-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name ACA

1.2 Other means of identification

Product number -
Other names 4-amylcinnamoylanthranilicacid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:110683-10-8 SDS

110683-10-8Downstream Products

110683-10-8Relevant articles and documents

Carboxylic acid amides, pharmaceutical compositions containing these compounds and their use

-

, (2008/06/13)

Carboxylic acid amides of general formula which inhibit telomerase and are useful for treating tumour diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are: (1) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-phenyl)-amide, and, (2) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-4,5-dimethoxy-phenyl)-amide.

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