850221-91-9

Upstream product

• 850221-90-8 2-chloro-3-(4-methoxyphenyl)-5,6-di-(1-oxo-[4-methoxyphenyl]methyl)pyrazine 
• 123-11-5 4-methoxy-benzaldehyde 
• 5910-89-4 2,3-dimethylpyrazine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 1425038-45-4 5-(4-methoxyphenyl)pyrazine-2,3-dicarbaldehyde 
• 1391986-80-3 5-(4-methoxyphenyl)-2,3-dimethylpyrazine 
• 1027521-19-2 {5,6-dichloro-3-[hydroxy-(4-methoxy-phenyl)-methyl]-pyrazin-2-yl}-(4-methoxy-phenyl)-methanol 
• 850221-89-5 2,3-dichloro-5,6-di-(1-oxo-[4-methoxyphenyl]methyl)pyrazine 
• 850221-88-4 2,3-dichloro-5-(1-hydroxy-[4-methoxyphenyl]methyl)pyrazine 

Relevant academic research and scientific papers

Synthesis and aldose reductase inhibitory activity of botryllazine A derivatives

Aldose reductase (AR) is associated with the onset of diabetic complications. Botryllazine A and its analogues were synthesized and evaluated for human AR inhibitory activity. Analogues possessing aromatic bicyclic systems at the C5 position of the centra

Iron-catalyzed cross-coupling of electron-deficient heterocycles and quinone with organoboron species via innate C-H functionalization: Application in total synthesis of pyrazine alkaloid botryllazine A

Here, we report an iron-catalyzed cross-coupling reaction of electron-deficient heterocycles and quinone with organoboron species via innate C-H functionalization. Iron(II) acetylacetonate along with oxidant (K 2S2O8) and phase-transfer catalyst (TBAB) under open flask conditions efficiently catalyzed the cross-coupling of pyrazine with arylboronic acids and gave monoarylated products in good to excellent yields. Optimized conditions also worked for other heterocylces such as quinoxalines, pyridines, quinoline, and isoquinoline as well as quinones. In addition, we demonstrated as a first example its application for the synthesis of anticancer marine pyrazine alkaloid botryllazine A.

Synthesis of pyrazine alcaloids from Botryllus leachi. diazines 43

(Chemical Equation Presented) Regioselective metalation of pyrazines and cross-coupling reactions provides an easy access to botryllazines A and B and to an isomer of botryllazine A with good yields from chloropyrazine.