850346-64-4

Upstream product

• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 171734-72-8 toluene-4-sulfonic acid 2-(2-bromophenyl)ethyl ester 
• 1074-16-4 2-bromophenylethyl alcohol 
• 1074-15-3 1-bromo-2-(2-bromoethyl)benzene 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 

Downstream Products

• 1211828-97-5 N-(2-bromophenethyl)-2-pyrrolecarboxylic acid 
• 850346-66-6 1,2-bis-(4-isopropoxy-phenyl)-5,6-dihydro-pyrrolo[2,1-a]isoquinoline-3-carboxylic acid methyl ester 
• 850346-65-5 1-(4-isopropoxy-phenyl)-5,6-dihydro-pyrrolo[2,1-a]isoquinoline-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

5,6-Dihydropyrrolo[2,1-b]isoquinolines as scaffolds for synthesis of lamellarin analogues

Efficient modular synthetic routes to open chain marine alkaloids such as lamellarins have been developed. 5,6-Dihydropyrrolo[2,1-b]isoquinoline scaffolds were prepared, and protocols enabling regioselective bromination followed by Suzuki cross-coupling were established for the introduction of aryl groups onto the 2- and 3-positions.

Palladium-catalyzed decarboxylative cross-coupling reaction between heteroaromatic Carboxylic acids and Aryl halides

"Chemical Equation Presented" A full overview of the decarboxylative cross-coupling reaction between heteroaromatic carboxylic acids and aryl halides is described. This transformation employs palladium catalysts with short reaction times providing facile synthesis of aryl-substituted heteroaromatics. The effect of each reaction parameter including solvent, base, and additive employed as well as the full substrate scope of this transformation are reported. Mechanistic evidence is also disclosed that sheds light on possible reaction pathways.