850352-53-3

Basic information

• Product Name: O-2482
• Synonyms: O-2482;1-(2-naphthalenyl)-2-(1-pyrrolidinyl)-1-Pentanone;0-2482;naphthylpyrovalerone;naphyrone;nrg-1;NRG-2;1-(Naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one
• CAS NO: 850352-53-3
• Molecular Formula: C19H23NO
• Molecular Weight: 281.39202
• EINECS: -0
• Product Categories: Research Chemical;Chemical for Research
• Mol File: 850352-53-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 430.5°C at 760 mmHg
• Flash Point: 161.4°C
• Appearance: /
• Density: 1.088g/cm³
• Vapor Pressure: 1.29E-07mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: O-2482(CAS DataBase Reference)
• NIST Chemistry Reference: O-2482(850352-53-3)
• EPA Substance Registry System: O-2482(850352-53-3)

Safety Data

• Hazardous Substances Data: 850352-53-3(Hazardous Substances Data)

Usage

General Description

O-2482 refers to a class of synthetic opioids that are structurally related to fentanyl and its analogs. These chemicals are potent opioid receptor agonists and have been associated with a high risk of overdose and death due to their powerful effect on the central nervous system. O-2482 and its analogs have been implicated in numerous cases of illicit drug use and have been the subject of concern for public health officials due to their potential for abuse and addiction. These chemicals have been classified as controlled substances and are regulated by legal authorities in an effort to reduce their availability and prevent their misuse.

InChI:InChI=1/C19H23NO/c1-2-7-18(20-12-5-6-13-20)19(21)17-11-10-15-8-3-4-9-16(15)14-17/h3-4,8-11,14,18H,2,5-7,12-13H2,1H3

Upstream product

• 33489-63-3 1-naphthalen-2-yl-pentan-1-one 
• 613-46-7 2-naphthalenecarbonitrile 
• 123-75-1 pyrrolidine 
• 850352-43-1 2-bromo-1-naphthalen-2-yl-pentan-1-one 

Relevant articles and documents

1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (pyrovalerone) analogues: A promising class of monoamine uptake inhibitors

Dopamine, serotonin, and norepinephrine are essential for neurotransmission in the mammalian system. These three neurotransmitters have been the focus of considerable research because the modulation of their production and their interaction at monoamine receptors has profound effects upon a multitude of pharmacological outcomes. Our interest has focused on neurotransmitter reuptake mechanisms in a search for medications for cocaine abuse. Herein we describe the synthesis and biological evaluation of an array of 2-aminopentanophenones. This array has yielded selective inhibitors of the dopamine and norepinephrine transporters with little effect upon serotonin trafficking. A subset of compounds had no significant affinity at 5HT1A, 5HT1B, 5HT1C, D1, D2, or D3 receptors. The lead compound, racemic 1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one 4a, was resolved into its enantiomers and the S isomer was found to be the most biologically active enantiomer. Among the most potent of these DAT/NET selective compounds are the 1-(3,4-dichlorophenyl)- (4u) and the 1-naphthyl- (4t) 2-pyrrolidin-1-yl-pentan-1-one analogues.