85045-43-8

Basic information

• Product Name: Benzenesulfonamide, 2,4,6-trimethyl-N-(phenylmethyl)-
• Synonyms: Benzenesulfonamide, 2,4,6-trimethyl-N-(phenylmethyl)-
• CAS NO: 85045-43-8
• Molecular Formula: C₁₆H₁₉NO₂S
• Molecular Weight: 289.39256
• Mol File: 85045-43-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenesulfonamide, 2,4,6-trimethyl-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 2,4,6-trimethyl-N-(phenylmethyl)-(85045-43-8)
• EPA Substance Registry System: Benzenesulfonamide, 2,4,6-trimethyl-N-(phenylmethyl)-(85045-43-8)

Safety Data

• Hazardous Substances Data: 85045-43-8(Hazardous Substances Data)

Upstream product

• 4543-58-2 2,4,6-trimethylbenzenesulfonamide 
• 100-51-6 benzyl alcohol 
• 1286686-17-6 potassium 2,4,6-trimethylphenylsulfonamidomethyltrifluoroborate 
• 108-90-7 chlorobenzene 
• 640-60-8 toluene-4-sulfonic acid phenyl ester 
• 17763-67-6 Phenyl triflate 
• 16156-59-5 phenyl methanesulfonate 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 773-64-8 2-mesitylenesulphonyl chloride 
• 100-46-9 benzylamine 

Downstream Products

• 148838-27-1 N-2,4,6-trimethylphenylsulfonylbenzaldimine 

Relevant articles and documents

Cobalt-Catalyzed 1,4-Aryl Migration/Desulfonylation Cascade: Synthesis of α-Aryl Amides

A cobalt-catalyzed 1,4-aryl migration/disulfonylation cascade applied to α-bromo N-sulfonyl amides was developed. The reaction was highly chemoselective, allowing the preparation of α-aryl amides possessing a variety of functional groups. The method was used as the key step to synthesize an alkaloid, (±)-deoxyeseroline. Mechanistic investigations suggest a radical process.

Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols

An efficient manganese-catalyzed N-alkylation of sulfonamides has been developed. This borrowing hydrogen approach employs a well-defined and bench-stable Mn(I) PNP pincer precatalyst, allowing benzylic and simple primary aliphatic alcohols to be employed as alkylating agents. A diverse range of aryl and alkyl sulfonamides undergoes mono-N-alkylation in excellent isolated yields (32 examples, 85% average yield).

Synthesis and cross-coupling of sulfonamidomethyltrifluoroborates

Sulfonamidomethyltrifluoroborates were successfully synthesized and cross-coupled with a wide range of aryl and heteroaryl chlorides, allowing the construction of a sulfonamidomethyl aryl linkage through a new disconnection, thus offering a new way to acc