850628-76-1 Usage
Uses
Used in Pharmaceutical Research and Development:
5-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one is used as a key compound in pharmaceutical research and development for its potential role in the creation of new drugs. Its unique structure and properties make it a valuable asset in the discovery and design of novel therapeutic agents.
Used in Drug Discovery:
In the Drug Discovery industry, 5-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one is utilized as a starting material or intermediate in the synthesis of various drug candidates. Its heterocyclic nature and potential biological activities contribute to the development of new chemical entities with therapeutic potential.
Used in Medicinal Chemistry:
5-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one is employed as a building block in medicinal chemistry for the design and optimization of drug molecules. Its structural features can be modified to enhance the pharmacological properties of the resulting compounds, leading to improved efficacy and safety profiles.
Used in Biological Research:
In the field of biological research, 5-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one is used as a tool compound to study its interactions with biological targets and to elucidate its mechanism of action. This research can provide valuable insights into the development of new therapeutic agents and the understanding of disease pathways.
Used in Therapeutic Development:
5-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one is utilized in the development of therapeutic agents for various diseases and conditions. Its potential biological activities and therapeutic properties make it a promising candidate for the treatment of a range of medical disorders, warranting further investigation and development.
Check Digit Verification of cas no
The CAS Registry Mumber 850628-76-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,0,6,2 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 850628-76:
(8*8)+(7*5)+(6*0)+(5*6)+(4*2)+(3*8)+(2*7)+(1*6)=181
181 % 10 = 1
So 850628-76-1 is a valid CAS Registry Number.
850628-76-1Relevant articles and documents
Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4
VanderWel, Scott N.,Harvey, Patricia J.,McNamara, Dennis J.,Repine, Joseph T.,Keller, Paul R.,Quin III, John,Booth, R. John,Elliott, William L.,Dobrusin, Ellen M.,Fry, David W.,Toogood, Peter L.
, p. 2371 - 2387 (2005)
Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide an effective method for the treatment of proliferative diseases such as cancer. The pyrido[2,3-d]-pyrimidin-7-one template has been identified previously as a privileged structure for the inhibition of ATP-dependent kinases, and good potency against Cdks has been reported for representative examples. Obtaining selectivity for individual Cdk enzymes, particularly Cdk4, has been challenging. Here, we report that the introduction of a methyl substituent at the C-5 position of the pyrido[2,3-d]pvrimidin-7-one template is sufficient to confer excellent selectivity for Cdk4 vs other Cdks and representative tyrosine kinases. Further optimization led to the identification of highly potent and selective inhibitors of Cdk4 that exhibit potent antiproliferative activity against human tumor cells in vitro. The most selective Cdk4 inhibitors were evaluated for antitumor activity against MDA-MB-435 human breast carcinoma xenografts in mice.
