850894-93-8Relevant academic research and scientific papers
Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation
Friden-Saxin, Maria,Pemberton, Nils,Da Silva Andersson, Krystle,Dyrager, Christine,Friberg, Annika,Grotli, Morten,Luthman, Kristina
supporting information; experimental part, p. 2755 - 2759 (2009/08/15)
A base-promoted condensation between 2-hydroxyacetophenones and aliphatic aldehydes has been studied. The reaction has been optimized to afford 2-alkyl-substituted 4-chromanones in an efficient manner using microwave heating. Performing the reaction using
Synthetic N-pyridinyl(methyl)-indol-3-ylpropanamides as new potential immunosuppressive agents
Carbonnelle, Delphine,Lardic, Morgane,Dassonville, Alexandra,Verron, Elise,Petit, Jean-Yves,Duflos, Muriel,Lang, Francois
, p. 686 - 693 (2008/02/11)
Several N-pyridinyl(methyl)-indol-3-ylpropanamides were synthesized and pharmacological evaluations of their immunosuppressive potential were performed. Among thirteen compounds tested in vitro on murine T proliferation, three showed interesting inhibitin
Poly(ethylene glycol) (400) as superior solvent medium against ionic liquids for catalytic hydrogenations with PtO2
Chandrasekhar, Srivari,Prakash, Samala Jaya,Rao, Chennamaneni Lohitha
, p. 2196 - 2199 (2007/10/03)
Adams' catalyst in poly(ethylene glycol) (PEG) (400) has been found to be a superior solvent over the ionic liquids by severalfold in promoting the hydrogenation of various functional groups. Both the catalyst and PEG were recycled efficiently over 10 runs without loss of activity, and substrate cross contamination was not observed despite a change in the substrate four times.
New N-pyridinyl(methyl)-indolalkanamides acting as topical inflammation inhibitors
Dassonville, Alexandra,Bretéché, Anne,Evano, Johan,Duflos, Muriel,Le Baut, Guillaume,Grimaud, Nicole,Petit, Jean-Yves
, p. 5441 - 5444 (2007/10/03)
The authors have described the synthetic way to new N-pyridinyl(methyl) indolylpropanamides acting as non acidic NSAIDs. Pharmacomodulation was carried out at N-1 and C-5 of the indole ring and at the level of the propanamide chain. N-(pyridin-3-ylmethyl)-3-[5-chloro-1-(4-chlorobenzyl)-indol-3-yl]propanamide 32 represents one of the most potent compounds evaluated in the TPA-induced mouse ear swelling assay, with a level of activity higher than that of ibuprofen and comparable to that of dexamethasone.
