85103-31-7

Basic information

• Product Name: 5-BENZYL-1,3,4-THIADIAZOLE-2-THIOL
• Synonyms: RARECHEM BG FB 0149;5-BENZYL-1,3,4-THIADIAZOLE-2-THIOL;5-BENZYL-1,3,4-THIADIAZOL-2-YL HYDROSULFIDE
• CAS NO: 85103-31-7
• Molecular Formula: C₉H₈N₂S₂
• Molecular Weight: 208.3
• Mol File: 85103-31-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-BENZYL-1,3,4-THIADIAZOLE-2-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BENZYL-1,3,4-THIADIAZOLE-2-THIOL(85103-31-7)
• EPA Substance Registry System: 5-BENZYL-1,3,4-THIADIAZOLE-2-THIOL(85103-31-7)

Safety Data

• Hazardous Substances Data: 85103-31-7(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 3619-22-5 p-toluic hydrazide 
• 38499-94-4 potassium 3-p-toluoyldithiocarbazate 

Downstream Products

• 91220-98-3 3-Hydroxymethyl-5-p-tolyl-3H-[1,3,4]thiadiazole-2-thione 
• 91220-99-4 3-Chloromethyl-5-p-tolyl-3H-[1,3,4]thiadiazole-2-thione 
• 91221-13-5 3-Morpholin-4-ylmethyl-5-p-tolyl-3H-[1,3,4]thiadiazole-2-thione 
• 91221-17-9 3-Phenylaminomethyl-5-p-tolyl-3H-[1,3,4]thiadiazol-2-one 
• 91221-11-3 3-Phenylaminomethyl-5-p-tolyl-3H-[1,3,4]thiadiazole-2-thione 
• 91221-04-4 3-Phenylsulfanylmethyl-5-p-tolyl-3H-[1,3,4]thiadiazole-2-thione 
• 91221-12-4 3-(Benzylamino-methyl)-5-p-tolyl-3H-[1,3,4]thiadiazole-2-thione 
• 91221-06-6 3-(Quinolin-8-yloxymethyl)-5-p-tolyl-3H-[1,3,4]thiadiazole-2-thione 
• 91221-14-6 3-(Quinolin-5-ylaminomethyl)-5-p-tolyl-3H-[1,3,4]thiadiazole-2-thione 
• 1298111-39-3 5-p-methylphenyl-2-phenylmercapto-1,3,4-thiadiazole 

Relevant articles and documents

Synthesis, antifungal activity and 3D-QSAR study of novel nopol-based 1,3,4-thiadiazole–thioether compounds

A series of novel nopol derivatives containing 1,3,4-thiadiazole–thioether moiety were synthesized from β-pinene, which is a natural, abundant and renewable biomass resource. Their structures were characterized by FT-IR, 1H NMR, 13C NMR, ESI–MS and elemental analysis. In vitro antifungal activity of the target compounds was preliminarily evaluated against eight tested plant pathogens, including Fusarium oxysporum f. sp. cucumerinum, Cercospora arachidicola, Physalospora piricola, Alternaria solani, Gibberella zeae, Rhizoeotnia solani, Bipolaris maydis and Colleterichum orbicalare. The bioassay results revealed that, at the concentration of 50?μg/mL, all the target compounds showed certain inhibition activity against the eight tested fungi. Compounds 5f (R = m–OCH3), 5i (R = m–F) and 5r (R = m–I) had excellent inhibition rates of 77.8%, 88.9% and 77.8%, respectively, against P. piricola, showing much better antifungal activity than that of the positive control chlorothalonil. Meanwhile, compound 5?m (R = p–Cl) displayed antifungal activity of 80.7% against R. solani. Furthermore, the analysis of three-dimensional quantitative structure–activity relationship (3D-QSAR) was performed for the relationship between the structures of the target compounds and their antifungal activity against P. piricola by CoMFA method. A reasonable CoMFA model (n = 6; q2 = 0.597; r2 = 0.985) was established.

Heterocyclic amplifiers of phleomycin. V. Thiadiazolylpyridines and related compounds; Preliminary antitumour results

-