85103-39-5

Basic information

• Product Name: Benzoic acid, 2-methyl-, 2-(dithiocarboxy)hydrazide, monopotassium salt
• CAS NO: 85103-39-5
• Molecular Formula: C9H10N2OS2.K
• Molecular Weight: 264.414
• Mol File: 85103-39-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-methyl-, 2-(dithiocarboxy)hydrazide, monopotassium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-methyl-, 2-(dithiocarboxy)hydrazide, monopotassium salt(85103-39-5)
• EPA Substance Registry System: Benzoic acid, 2-methyl-, 2-(dithiocarboxy)hydrazide, monopotassium salt(85103-39-5)

Safety Data

• Hazardous Substances Data: 85103-39-5(Hazardous Substances Data)

Upstream product

• 87-24-1 ethyl 2-methylbenzoate 
• 933-88-0 ortho-toluoyl chloride 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 118-90-1 ortho-methylbenzoic acid 
• 75-15-0 carbon disulfide 
• 7658-80-2 2-methylbenzohydrazide 

Downstream Products

• 87239-95-0 4-amino-5-(2-methylphenyl)-4H-1,2,4-triazole-3-thiol 
• 87239-95-0 4-amino-2,4-dihydro-5-(2-methylphenyl)-3H-1,2,4-triazole-3-thione 
• 76779-96-9 5-(2-methylphenyl)-1,3,4-thiadiazole-2-thiol 
• 591734-70-2 N'-(2-methylbenzoyl)-hydrazinecarbodithioic acid methyl ester 
• 2503-66-4 5-(2-methylphenyl)-1,3,4-oxadiazole-2-thiol 

Relevant articles and documents

5-substituent-1, 2, 4-triazole-thioketone Schiff base compound as well as preparation method and application thereof

The invention belongs to the technical field of chemical medicines, and relates to a 5-substituent 1, 2, 4-triazole thioketone Schiff base compound as well as a preparation method and application thereof. An intermediate (I) or an intermediate (II) is subjected to reflux reaction with 3, 5-dimethyl 4-hydroxy benzaldehyde in glacial acetic acid respectively, filtering and drying are performed to obtain the 5-substituent -1, 2, 4-triazole thioketone Schiff base compound. According to the 5-substituent-1, 2, 4-triazole-thioketone Schiff base compound as well as the preparation method and application thereof of the invention, an active group-- imino is introduced into a triazole ring matrix to prepare and synthesize a series of triazole Schiff base compounds with multiple active sites, and thetriazole Schiff base compounds have the advantages of good activity, small dosage, small toxic and side effects, safety and environmental protection; meanwhile, the compounds can be used as crop antifungal agents and can influence the synthesis of fungal cell walls, so that the growth and proliferation of fungi are inhibited, and finally, an antibacterial or bactericidal effect is achieved.

Synthesis and Biological Evaluation of Kojic Acid Derivatives Containing 1,2,4-triazole as Potent Tyrosinase Inhibitors

A series of 5-substituted-3-[5-hydroxy-4-pyrone-2-yl-methymercapto]-4-amino-1,2,4-triazole derivatives were synthesized by nucleophilic substitution reaction of 5-hydroxy-2-chloromethyl -4H-pyran-4-one with 5-substituted-3-mercapto-4-amino-1,2,4-triazole,

Synthesis and evaluation of antioxidant properties of novel 1,2,4-triazole-based schiff base heterocycles

A series of 1,2,4-triazole-based Schiff base heterocyclic compounds (5a-f and 8a-i) and phenethylamines (7a-h) were synthesized and evaluated for antioxidant properties by free-radical scavenging, anti-hemolytic activity, lipid peroxidation, and their protective effects against DNA oxidative damage. Compounds 7c, 7d, 7h, 8b, and 8i showed promising DPPH? radical scavenging activity with the level of inhibition between 86.8% and 94%. Compounds 8a, 8b, 8d, 8g, and 8i were effective against the oxidative hemolysis of human erythrocytes and lipid peroxidation, in a dose-dependent manner, with IC50 values in the range of 55.7-80.7 and 53.2-81.2 μg/mL, respectively. Compounds 8a and 8b were effective against oxidative damage on erythrocyte ghost membrane proteins, and 8g and 8i were able to protect against DNA oxidative damage. 1,2,4-Triazole based Schiff base heterocycles (5a-f, 8a-i) and phenethylamines (7a-h) were synthesized and evaluated for their antioxidant properties by free-radical scavenging, anti-hemolytic activity, lipid peroxidation, and their protective effects against DNA oxidative damage.