851075-68-8Relevant academic research and scientific papers
An improved synthesis of (1R,3S)-3-[(tert-butoxycarbonyl)amino] cyclohexanecarboxylic acid
Badland, Matthew,Bains, Carol A.,Howard, Roger,Laity, Daniel,Newman, Sandra D.
scheme or table, p. 864 - 866 (2010/11/02)
An improved synthesis of (1R,3S)-3-[(tert-butoxycarbonyl)amino] cyclohexanecarboxylic acid from 3-aminobenzoic acid is described utilising milder and more selective conditions. Both a classical salt resolution and an enzymatic approach have been shown to give the desired compound in high selectivity.
Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure
Yamazaki, Kazuo,Kaneko, Yasushi,Suwa, Kie,Ebara, Shinji,Nakazawa, Kyoko,Yasuno, Kazuhiro
, p. 2509 - 2522 (2007/10/03)
Two parallel synthetic methods using solid-supported reagents were established to examine the rapid optimization of weak hit compound 1. Several compounds showed high potency in the low nanomolar range against N-myristoyltransferase. The structure-activity relationship (SAR) and antifungal activities of a series of novel 2-aminobenzothiazole N-myristoyltransferase inhibitors are presented.
