222530-39-4

Usage

Uses

Used in Organic Synthesis:
CYCLOHEXANECARBOXYLIC ACID, 3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-, (1R,3S)is utilized as a key intermediate in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for the formation of multiple chemical bonds and reactions, making it a valuable component in the synthesis of specialty chemicals and pharmaceuticals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, CYCLOHEXANECARBOXYLIC ACID, 3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-, (1R,3S)serves as a crucial building block for the development of new drugs. Its specific stereochemistry and functional groups can be leveraged to design molecules with targeted therapeutic effects, potentially leading to the discovery of novel treatments for various diseases.
Used in Drug Development:
CYCLOHEXANECARBOXYLIC ACID, 3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-, (1R,3S)-'s potential applications in drug development are vast due to its unique structural features. CYCLOHEXANECARBOXYLIC ACID, 3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-, (1R,3S)can be modified and optimized to create new drug candidates with improved pharmacological properties, such as enhanced efficacy, selectivity, and reduced side effects.
Used in Material Science:
Beyond its applications in organic synthesis and pharmaceuticals, CYCLOHEXANECARBOXYLIC ACID, 3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-, (1R,3S)may also find use in the development of new materials. Its structural properties could be harnessed to create innovative materials with unique characteristics for use in various industries, such as coatings, adhesives, or polymers.

Upstream product

• 218772-92-0 (±)-cis-3-((tert-butoxycarbonyl)amino)cyclohexanecarboxylic acid 
• 16636-51-4 (+/-)-cis-3-aminocyclohexanecarboxylic acid 
• 121-92-6 3-nitrobenzoic acid 
• 862401-49-8 cis-3-aminocyclohexanecarboxylic acid hydrochloride 
• 1312544-21-0 C₈H₁₁N*C₁₂H₂₁NO₄ 
• 227783-08-6 (1S,3R)-3-ethoxycarbonylcyclohexane-1-carboxylic acid 
• 62059-56-7 cis-1,3-Cyclohexanedicarboxylic acid diethyl ester 
• 99-05-8 meta-aminobenzoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 851075-68-8 ethyl (1R,3S)-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate 

Downstream Products

• 851075-70-2 tert-butyl N-(1R,3S)-3-[(2-[(cyclopentylcarbonyl)amino]-benzothiazol-6-ylamino)carbonyl]cyclohexyl carbamate 
• 81131-39-7 (+/-)-cis-3-Aminocyclohexanecarboxylic acid 
• 511547-46-9 (1R,3S)-3-[(tert-butyloxycarbonyl)methylamino]cyclohexanecarboxylic acid 
• 1202411-51-5 tert-butyl {(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}carbamate 
• 1409956-93-9 Boc-L-γ-Ach-D-γ-^MeN-Acp-OFm 

Relevant academic research and scientific papers

Synthesis of cyclic γ-amino acids for foldamers and peptide nanotubes

Cyclic γ-amino acids are molecular building blocks of great interest in peptide and foldamer chemistry, as they allow the preparation of new structures that are not found in Nature. In this paper, we describe the synthesis of cyclic γ-amino acids that have a cis relationship between the amino and the carboxylic acid groups. This arrangement, in most cases, induces the resulting peptides to adopt a flat conformation, which makes them appropriate for the design of foldamers that adopt β-sheet-type structures. We describe the synthesis of cyclic γ-amino acids that have a cis relationship between the amino and the carboxylic acid groups. This makes them suitable for the design of foldamers that adopt β-sheet-type structures.

An improved synthesis of (1R,3S)-3-[(tert-butoxycarbonyl)amino] cyclohexanecarboxylic acid

An improved synthesis of (1R,3S)-3-[(tert-butoxycarbonyl)amino] cyclohexanecarboxylic acid from 3-aminobenzoic acid is described utilising milder and more selective conditions. Both a classical salt resolution and an enzymatic approach have been shown to give the desired compound in high selectivity.

Self-assembled peptide tubelets with 7 A pores

Here we report the preparation and structural characteristics of self-assembling peptide tubelets composed of 32-membered rings formed of alternating cx-amino acids and cis-3-aminocyclohexanecarboxylic acids. The tubelets possess a partial hydrophobic cor

Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure

Two parallel synthetic methods using solid-supported reagents were established to examine the rapid optimization of weak hit compound 1. Several compounds showed high potency in the low nanomolar range against N-myristoyltransferase. The structure-activity relationship (SAR) and antifungal activities of a series of novel 2-aminobenzothiazole N-myristoyltransferase inhibitors are presented.

New cyclic peptide assemblies with hydrophobic cavities: The structural and thermodynamic basis of a new class of peptide nanotubes

A new class of self-assembling peptides based on cyclic peptides made of alternating 3-aminocyclohexanecarboxylic acid (γ-Acc) and α-amino acids is described. The studied cylindrical assemblies are models for a new class of self-assembling peptide nanotub