85111-06-4Relevant articles and documents
One-Pot Synthesis of N-(α-Peroxy)Indole/Carbazole via Chemoselective Three-Component Condensation Reaction in Open Atmosphere
Wang, Xinbo,Pan, Yupeng,Huang, Kuo-Wei,Lai, Zhiping
, p. 5630 - 5633 (2015)
A facile one-pot synthesis of N-(α-peroxy)indole and N-(α-peroxy)carbazole has been developed using metal-free, organo-acid-catalyzed three-component condensation reactions of indole/carbazole, aldehyde, and peroxide. Based on the reaction discovered, a new synthetic proposal for Fumitremorgin A and Verruculogen is introduced. Such a protocol could be easily handled and scaled up in an open atmosphere with a wide substrate scope, enabling the construction of a new molecule library.
Copper-catalyzed synthesis of 2,3-disubstituted indoles from ortho-haloanilines and β-keto esters/β-diketone
Liu, Xiao-Guang,Li, Zi-Hao,Xie, Jian-Wei,Liu, Ping,Zhang, Jie,Dai, Bin
supporting information, p. 653 - 657 (2016/01/15)
Tetrazole-1-acetic acid was identified as an efficient ligand to promote copper-catalyzed domino reaction of ortho-iodo/bromo-anilines with β-keto esters/β-diketone for 2,3-disubstituted indoles' synthesis with high yields under mild conditions. The proto
